Faster walking speeds increase local instability among people with peripheral neuropathy

Journal of Biomechanics
Brad ManorLi Li

Abstract

Individuals with peripheral neuropathy (PN) may compensate for decreased somatosensation by reducing walking speed. Predisposition to falls may therefore arise from an inability to adapt to challenging walking speeds. The purpose of this study was to examine the effects of PN on the magnitude of variability and local instability on walking at different speeds. Twelve individuals with PN and 12 controls completed a 6-min walk test to determine fast walking speed (FWS). Sagittal plane hip, knee, and ankle joint angles were then calculated during 3 min of treadmill walking at 100%, 80%, and 60% FWS. The magnitudes of stride duration variability (SDvar), joint angle variability (JTvar), and both short- and long-term Lyapunov exponents (used to estimate local instability) were calculated. The PN group walked slower than the control group (p<.001). With groups combined, walking faster led to increased local instability and increased variability (p<.001). The PN group exhibited increased variability (SDvar, p=.02; JTvar, p=.01) over all speeds, and exaggerated local instability (p<.05) when walking at the fastest speed. PN leads to increased walking variability and local instability, particularly when walking at challenging speeds. Th...Continue Reading

References

Jun 1, 1992·Diabetic Medicine : a Journal of the British Diabetic Association·P R CavanaghT J Orchard
Sep 17, 2002·Journal of Biomechanics·Eric EilsDieter Rosenbaum
Jun 5, 2003·Chaos·Jonathan B. Dingwell, Joseph P. Cusumano
Feb 18, 2004·Archives of Physical Medicine and Rehabilitation·Hylton B MenzRichard C Fitzpatrick
Dec 1, 1983·Journal of Motor Behavior·D A Winter
May 27, 2004·Diabetes Care·Andrew J M BoultonJay M Sosenko
Sep 3, 2004·Journal of the American Geriatrics Society·James K RichardsonJames A Ashton-Miller
Jan 12, 2005·Journal of Diabetes and Its Complications·Nozomu KameiNobuoki Kohno
May 18, 2005·Human Movement Science·Li LiJoseph Hamill
Jun 7, 2005·Seminars in Neurology·Gregory T Carter
Jan 4, 2006·Journal of Biomechanics·Jonathan B Dingwell, Laura C Marin
Apr 20, 2006·Gait & Posture·Scott A England, Kevin P Granata
Jan 26, 2007·American Journal of Physical Medicine & Rehabilitation·Trina K DeMottJames A Ashton-Miller
Feb 1, 2002·Integrative and Comparative Biology·Robert J FullDaniel Koditschek

❮ Previous
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Citations

May 15, 2013·Medical Engineering & Physics·Sayed Naseel Mohamed ThangalSriram Balasubramanian
Jan 21, 2010·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Marco PaoloniValter Santilli
May 27, 2010·The American Journal of Chinese Medicine·Li Li, Brad Manor
Apr 1, 2014·Journal of Biomechanics·Rainer BeurskensJonathan B Dingwell
Oct 15, 2014·Journal of Biomechanics·Jan StenumBente R Jensen
Jan 3, 2015·European Journal of Sport Science·Sina MehdizadehKeith Davids
Feb 7, 2013·Archives of Physical Medicine and Rehabilitation·Tine Roman de MettelingeDirk Cambier
Jul 11, 2012·Journal of Biomechanics·Espen A F IhlenBeatrix Vereijken
Aug 23, 2011·Medical Engineering & Physics·Sjoerd M BruijnJaap H van Dieën
Apr 22, 2009·Journal of Biomechanics·Deanna H Gates, Jonathan B Dingwell
Dec 3, 2014·Archives of Physical Medicine and Rehabilitation·Lewis A LipsitzBrad Manor
Oct 15, 2013·Human Movement Science·Paulien E Roos, Jonathan B Dingwell
Jul 4, 2012·Journal of Biomechanics·Emily H SinitksiJonathan B Dingwell
Aug 16, 2016·BioMed Research International·Amirah MustapaHaidzir Manaf
May 16, 2014·Journal of the American Geriatrics Society·Chun-Mei Xiao
May 12, 2017·Rehabilitation Research and Practice·Amirah MustapaHaidzir Manaf
Jul 28, 2013·Journal of the International Association of Providers of AIDS Care·Roberto SandovalCarolyn Kelley

❮ Previous
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