Fastigial nucleus stimulation regulates neuroprotection via induction of a novel microRNA, rno-miR-676-1, in middle cerebral artery occlusion rats

Journal of Neurochemistry
Xiao-Min PangSheng-You Su

Abstract

Previous studies have shown that fastigial nucleus stimulation (FNS) reduces tissue damage resulting from focal cerebral ischemia. Although the mechanisms of neuroprotection induced by FNS are not entirely understood, important data have been presented in the past two decades. MicroRNAs (miRNAs) are a newly discovered group of non-coding small RNA molecules that negatively regulate target gene expression and are involved in the regulation of cell proliferation and cell apoptosis. To date, no studies have demonstrated whether miRNAs can serve as mediators of the brain's response to FNS, which leads to endogenous neuroprotection. Therefore, this study investigated the profiles of FNS-mediated miRNAs. Using a combination of deep sequencing and microarray with computational analysis, we identified a novel miRNA in the rat ischemic cortex after 1 h of FNS. This novel miRNA (PC-3p-3469_406), herein referred to as rno-miR-676-1, was upregulated in rats with cerebral ischemia after FNS. In vivo observations indicate that this novel miRNA may have antiapoptotic effects and contribute to neuroprotection induced by FNS. Our study provides a better understanding of neuroprotection induced by FNS. MicroRNA (miRNA) is defined as a small non-...Continue Reading

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Citations

Feb 20, 2016·Molecular Neurobiology·Zhiping HuLiuwang Zeng
Aug 10, 2016·Biochimica Et Biophysica Acta·Murali Vijayan, P Hemachandra Reddy
Oct 27, 2018·Cell Transplantation·Sheng-Wen WangZhong-Song Shi
May 18, 2019·Proteomics. Clinical Applications·Xiao-Min PangJing-Li Liu
Aug 30, 2016·Drug Development Research·David Gurwitz
Oct 13, 2017·Journal of Neurotrauma·Venkata Siva Sai Sujith SajjaMiroslaw Janowski

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