Fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are highly familial traits.

Diabetologia
A P GjesingT Hansen

Abstract

Heritability estimates have shown a varying degree of genetic contribution to traits related to type 2 diabetes. Therefore, the objective of this study was to investigate the familiality of fasting and stimulated measures of plasma glucose, serum insulin, serum C-peptide, plasma glucose-dependent insulinotropic polypeptide (GIP) and plasma glucagon-like peptide-1 (GLP-1) among non-diabetic relatives of Danish type 2 diabetic patients. Sixty-one families comprising 193 non-diabetic offspring, 29 non-diabetic spouses, 72 non-diabetic relatives (parent, sibling, etc.) and two non-related relatives underwent a 4 h 75 g OGTT with measurements of plasma glucose, serum insulin, serum C-peptide, plasma GIP and plasma GLP-1 levels at 18 time points. Insulin secretion rates (ISR) and beta cell responses to glucose, GIP and GLP-1 were calculated. Familiality was estimated based on OGTT-derived measures. A high level of familiality was observed during the OGTT for plasma levels of GIP and GLP-1, with peak familiality values of 74 ± 16% and 65 ± 15%, respectively (h (2) ± SE). Familiality values were lower for plasma glucose, serum insulin and serum C-peptide during the OGTT (range 8-48%, 14-44% and 15-61%, respectively). ISR presented the ...Continue Reading

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Citations

Aug 6, 2014·Biochimica Et Biophysica Acta·Jose Manuel García-MartínezCustodia García-Jiménez
Nov 3, 2017·JCI Insight·Peter AlmgrenEmma Ahlqvist
Aug 24, 2019·The Journal of International Medical Research·Simona FerjanAndrej Janez
Jul 31, 2020·JCI Insight·Francis S WillardKyle W Sloop
Sep 25, 2019·Clinical Medicine Insights. Endocrinology and Diabetes·R A PerryN Irwin
Sep 19, 2020·The Journal of Clinical Endocrinology and Metabolism·Harshal A DeshmukhMark Walker
Nov 13, 2020·Proceedings of the National Academy of Sciences of the United States of America·Takahiro KawaiKyle W Sloop
Sep 24, 2020·Endocrinology·Kimberley ElJonathan E Campbell

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