PMID: 8580923Dec 1, 1995Paper

Fasting and postprandial cerebrospinal fluid glucose concentrations in healthy women and in an obese binge eater

The International Journal of Eating Disorders
T D GeraciotiN N Ekhator

Abstract

We hypothesized that abnormal entry of glucose into the central nervous system (CNS) might exist in some chronic binge eaters of carbohydrates, as either a cause or consequence of binge eating. The purpose of this study was thus to determine fasting and postprandial glucose concentrations in the cerebrospinal fluid (CSF) of healthy women, and to obtain similar data in an obese, irritable woman with chronic binge eating of postpartum onset. CSF was sampled continuously at 0.1 ml/min from 1100 hr to 1700 hr from the binge eating patient, who consumed 5,000 to 10,000 calories per day (preferentially binging on refined carbohydrates), and 4 healthy women via an indwelling, flexible spinal canal catheter. CSF aliquots were obtained at 10-min intervals for measurement of glucose concentrations. Simultaneously, blood was withdrawn at 30-min intervals to obtain serum for glucose assay. A glucose-rich mixed liquid meal was consumed by participants at 1300 hr. In striking contrast to the normal women, our bulimic patient showed no postprandial rise whatever in CSF glucose concentrations. Fasting CSF glucose concentrations were slightly lower whereas fasting serum glucose levels were normal in the bulimic patient, compared with the normal...Continue Reading

Citations

Feb 17, 1998·Trends in Neurosciences·D M Kullmann, F Asztely
Nov 8, 2013·Journal of Neurogastroenterology and Motility·Jing ZhangJiande D Z Chen
Jul 26, 2014·The International Journal of Eating Disorders·Anu RaevuoriJaana Suvisaari
Oct 1, 1997·Addiction Biology·T D GeraciotiP E Keck

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