Fasting hypometabolism and refeeding hyperphagia in rats: Effects of capsaicin desensitization of the abdominal vagus

European Journal of Pharmacology
Andras GaramiErika Pétervári

Abstract

Capsaicin-sensitive abdominal vagal fibers contribute to postprandial satiety and hypermetabolism. We hypothesized that the hypometabolic adaptation to fasting involves similar mechanisms and that blockade of such signals might enhance loss of body weight upon fasting. A low dosage of capsaicin (5mg/kg) administered intraperitoneally desensitizes the local afferent vagal nerve endings for approximately three weeks without causing systemic desensitization or damaging the efferent fibers. Following such desensitization, male Wistar rats deprived of food for 120h lost significantly (18.9 + or - 0.4% vs. 15.8 + or - 1.0%), i.e. 20% more weight than the controls. Based on the present results, this can only be explained by the demonstrated defective hypometabolic adaptation in desensitized animals. Other mechanisms do not seem to make up for this defective function. Upon refeeding following a period of fasting, in the first 0.5-3h the food intake was significantly greater in capsaicin pretreated compared to the control group, demonstrating blockade of satiety as a sign of desensitization. The delayed gastrointestinal passage supported that vagal afferent nerve endings were in a desensitized state in these rats. In conclusion, local d...Continue Reading

References

May 1, 1985·The Journal of Physiology·P L AndrewsM J Stock
Sep 21, 2000·The Proceedings of the Nutrition Society·G A Bray
Dec 13, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A A RomanovskyM Székely
Feb 24, 2001·Autonomic Neuroscience : Basic & Clinical·M SzékelyA A Romanovsky
Dec 26, 2001·Endocrinology·Catherine B LawrenceSimon M Luckman
May 17, 2003·Brain Research. Molecular Brain Research·Kevin L GroveJudy L Cameron
Aug 21, 2003·Autonomic Neuroscience : Basic & Clinical·Maria A ZafraAmadeo Puerto
Jan 22, 2005·Science·Michael W Schwartz, Daniel Porte
Jul 16, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B R GillespieR C Ritter
Aug 17, 2005·Current Protein & Peptide Science·M Székely, Z Szelényi
Nov 9, 2005·Peptides·Fabrice Bertile, Thierry Raclot
Jan 18, 2007·American Journal of Physiology. Endocrinology and Metabolism·Mario PerelloEduardo A Nillni
Jul 13, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexandre A SteinerAndrej A Romanovsky
Mar 4, 2009·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Mariona PalouAndreu Palou
Sep 15, 2009·Pharmacological Reviews·Andrej A RomanovskyTatiane B Nucci

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Citations

Jun 22, 2012·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Edward A Fox
Jul 31, 2013·Trends in Endocrinology and Metabolism : TEM·Gerard P Ahern
Mar 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Luigi BellocchioGiovanni Marsicano
Jul 28, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shaherin BasithSun Choi
Aug 4, 2011·Endocrinology·Victoria Scott, Colin H Brown
Apr 1, 2014·Temperature : Multidisciplinary Biomedical Journal·András Garami, Miklós Székely
May 26, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M BishnoiS K Panchal
Dec 30, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yusaku IwasakiToshihiko Yada

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