Fasting-induced impairment of glucose-1,6-bisphosphate synthesis in pancreatic islets

Biochemical and Biophysical Research Communications
M H GiroixW J Malaisse


In pancreatic islets removed from rats fasted for 48 hours, the insulin secretory response to glucose is decreased. Although the activity of phosphoglucomutase is unaffected by fasting, the decrease in glucose-stimulated insulin release coincides with a suppression of the glucose-induced increment in both glucose-1,6-P2 content and lactate or pyruvate output. These findings are compatible with a regulatory role of glucose-1,6-P2 in the control of glycolysis in pancreatic islets.


Apr 1, 1979·Metabolism: Clinical and Experimental·W J MalaisseJ C Hutton
Oct 1, 1973·Diabetologia·L A Idahl


Oct 15, 1984·Experientia·A Sener, W J Malaisse
Oct 15, 1984·Experientia·W J MalaisseA Sener
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·F ClimentJ Carreras
Oct 15, 1984·European Journal of Biochemistry·A SenerW J Malaisse
Aug 1, 1985·Diabetologia·W J Malaisse, A Sener
Oct 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Y SarriR Gomis
Jan 1, 1986·Diabetes/metabolism Reviews·M D Meglasson, F M Matschinsky
Apr 1, 1986·Cell Biochemistry and Function·A R CarpinelliW J Malaisse

Related Concepts

beta-D-glucose 1,6-(bis)phosphate
Anhydrous Dextrose
Glutamate Dehydrogenase
Insulin B Chain
Islets of Langerhans

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.