Fasting Ketonuria and the Risk of Incident Nonalcoholic Fatty Liver Disease With and Without Liver Fibrosis in Nondiabetic Adults.

The American Journal of Gastroenterology
Yejin KimSeungho Ryu

Abstract

Dietary carbohydrate restriction or ketogenic diets are known to be beneficial in preventing liver fat accumulation. However, the effect of ketonemia on the risk of nonalcoholic fatty liver disease (NAFLD) in nondiabetic population is largely unknown. We investigated the association between fasting ketonuria and the risk of incident NAFLD in healthy adults. A cohort of 153,076 nondiabetic Koreans with no hepatic steatosis and low probability of fibrosis at baseline was followed for a median of 4.1 years. The outcome was incident hepatic steatosis with or without liver fibrosis, and it was assessed by liver ultrasound and noninvasive fibrosis indices, including fibrosis-4 and the NAFLD fibrosis score (NFS). Parametric proportional hazard models were used to estimate hazard ratios (HRs) for outcome according to ketonuria status. Within 677,702.1 person-years of follow-up, 31,079 subjects developed hepatic steatosis. Compared with no ketonuria (reference), fasting ketonuria was significantly associated with a decreased risk of incident hepatic steatosis, with multivariable-adjusted HRs (95% confidence interval) of 0.81 (0.78-0.84). The corresponding HRs for incident hepatic steatosis with intermediate-to-high NFS were 0.79 (0.69-0...Continue Reading

References

Jan 15, 2000·Diabetes/metabolism Research and Reviews·L Laffel
Sep 19, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·U L MathiesenG Bodemar
May 23, 2003·The New England Journal of Medicine·Gary D FosterSamuel Klein
Jan 16, 2007·Digestive Diseases and Sciences·David TendlerEric C Westman
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul AnguloChristopher P Day
Mar 13, 2008·Journal of Hepatology·Laurent CasteraAlfredo Alberti
May 27, 2008·Journal of the International Society of Sports Nutrition·Anssi H Manninen
Apr 17, 2009·Obesity·Maarten R SoetersMireille J Serlie
Jun 16, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Amy G ShahUNKNOWN Nash Clinical Research Network
Dec 18, 2010·Journal of Korean Medical Science·Nam-Seok JooSang-Man Kim
Mar 4, 2011·The American Journal of Clinical Nutrition·Jeffrey D BrowningShawn C Burgess
May 28, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ruben HernaezJeanne M Clark
May 28, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mariëlle VerweijRon W F de Bruin
Jun 22, 2011·Journal of Medicinal Food·Joaquín Pérez-Guisado, Andrés Muñoz-Serrano
Mar 2, 2012·Journal of Korean Medical Science·Hyeon-Jeong KimSang-Man Kim
Sep 5, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Matthew J ArmstrongWing-Kin Syn
Oct 7, 2014·Frontline Gastroenterology·J K DysonS McPherson
Apr 29, 2015·Journal of Hepatology·Christopher D Byrne, Giovanni Targher
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tiffany GrecoMayumi L Prins
Mar 20, 2016·Gut·Elena Piccinin, Antonio Moschetta
Dec 3, 2016·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Fahimeh HaghighatdoostLeila Azadbakht
Feb 9, 2017·Cell Metabolism·Patrycja Puchalska, Peter A Crawford
May 17, 2017·Archives of Physiology and Biochemistry·Kei Nakajima, Eiji Oda
Mar 27, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Salvatore PettaSilvio Buscemi
Aug 22, 2018·Current Nutrition Reports·Victoria M GershuniValentina Medici
May 28, 2019·Liver Research·Bilon KhambuXiao-Ming Yin
Nov 2, 2019·Metabolism: Clinical and Experimental·Bradley TuckerKwok Leung Ong
Jan 29, 2020·JAMA : the Journal of the American Medical Association·Zhaoping Li, David Heber

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.