Fasting plasma triglyceride levels and fat oxidation predict dietary obesity in rats

Physiology & Behavior
H Ji, M I Friedman

Abstract

We investigated whether fuel metabolism prior to high-fat feeding differs in outbred Sprague-Dawley rats either prone or resistant to diet-induced obesity. Chow-fed rats were deprived of food, and blood was collected 12, 18, and 24 h later. Rats were then fed a high-fat diet ad libitum for up to 4 weeks to assess weight gain. Blood samples were analyzed for a variety of metabolic fuels and hormones. Only fasting plasma triglyceride concentrations showed a positive correlation with the weight gain during the high-fat feeding period, with concentrations after 18 h of fasting showing the most consistent relationship to weight gain. Body weights and fat pad weights did not correlate with fasting plasma triglyceride concentrations before high-fat feeding. The amount of 14CO(2) recovered from gavaged [14C]palmitic acid in chow-fed rats negatively correlated with weight gain during the subsequent period of high-fat feeding. These results show that there are preexisting differences in fat catabolism that may underlie differential susceptibility to diet-induced obesity; in particular, fasting levels of plasma triglycerides and fatty acid oxidation may be early predictive markers for this susceptibility.

References

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Citations

May 7, 2008·Journal of Physiology and Biochemistry·N Pérez-EcharriM J Moreno-Aliaga
Aug 23, 2007·The British Journal of Nutrition·Judith E Urías-SilvasNathalie M Delzenne
May 28, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H Ji, M I Friedman
Oct 25, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Arnaud BernardJean Demarquoy
Dec 6, 2011·The Journal of Nutritional Biochemistry·Xavier L LouisThomas Netticadan
Jun 3, 2008·Physiology & Behavior·Daniel H BessesenMarc A Cornier
Jul 10, 2007·Metabolism: Clinical and Experimental·Hong Ji, Mark I Friedman
Sep 12, 2017·Nutrients·Henry J ThompsonMark A Brick
May 2, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K L LeibowitzS F Leibowitz
Aug 20, 2005·Diabetes/metabolism Research and Reviews·Annemiek M C P JoosenKlaas R Westerterp
Jan 13, 2006·American Journal of Physiology. Endocrinology and Metabolism·S F LeibowitzP P Pamy
Jun 29, 2006·American Journal of Physiology. Endocrinology and Metabolism·Matthew R JackmanDaniel H Bessesen
Dec 24, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xiyuan ZhangYuan-Xiang Pan
Mar 8, 2007·American Journal of Physiology. Endocrinology and Metabolism·Robert C NolandRobert M Lust
Jan 18, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Jackie M Y HowDaniela M Sartor
Jun 22, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patrick C Even, Nachiket A Nadkarni
May 11, 2021·ILAR Journal·Corinna N RossSuzette Tardif

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