Fasting serum growth hormone and insulin-like growth factor-I and -II concentrations in women with leiomyomata uteri treated with leuprolide acetate or placebo

Fertility and Sterility
A J FriedmanR L Barbieri

Abstract

Eighteen patients with leiomyomata uteri were randomized to receive either leuprolide acetate depot (n = 9) 3.75 mg intramuscularly (IM) or placebo (n = 9) IM every 4 weeks for four injections. Leuprolide acetate treated patients demonstrated a reduction in mean uterine volume of 34% and a decrease in serum estradiol (E2) concentrations from 120 +/- 21 pg/mL (mean +/- standard error) to 16 +/- 9 pg/mL. Leuprolide acetate treated patients also demonstrated significant decreases in serum growth hormone (GH) (3.0 +/- 0.4 ng/mL versus 1.4 +/- 0.4 ng/mL) and insulin-like growth factor-I (IGF-I) concentrations (3.3 +/- 0.4 U/mL versus 1.3 +/- 0.2 U/mL) over the 12 week treatment period. Serum IGF-II levels did not change. Mean uterine volume and serum E2, GH, IGF-I, and IGF-II concentrations did not change in placebo-treated patients. These data suggest that hypoestrogenism is associated with decreases in circulating GH and IGF-I.

Citations

Apr 5, 2007·The Journal of Clinical Endocrinology and Metabolism·Johannes D VeldhuisCyril Y Bowers
Jun 1, 1991·Journal of in Vitro Fertilization and Embryo Transfer : IVF·Z Blumenfeld
Apr 20, 2006·American Journal of Physiology. Endocrinology and Metabolism·Michael J TothPeter R Casson
Dec 1, 1996·Journal of Endocrinological Investigation·P G ArtiniG D'Ambrogio
Oct 1, 1996·The Journal of Obstetrics and Gynaecology Research·M Y WuY S Yang
Feb 12, 2005·Journal of Assisted Reproduction and Genetics·Yao-Yuan HsiehChing-Tien Peng
Jun 28, 2003·Neurobiology of Aging·Johannes D Veldhuis
Nov 9, 2010·Taiwanese Journal of Obstetrics & Gynecology·Chi-Chen ChangChih-Sheng Lin

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