Fasting substrate oxidation at rest assessed by indirect calorimetry: is prior dietary macronutrient level and composition a confounder?

International Journal of Obesity : Journal of the International Association for the Study of Obesity
J L Miles-ChanY Schutz

Abstract

Indirect calorimetry, the measurement of O₂ consumption and CO₂ production, constitutes an invaluable tool as the most common method for analyzing whole-body energy expenditure, and also provides an index of the nature of macronutrient substrate oxidation--namely, carbohydrate (CHO) versus fat oxidation. The latter constitutes a key etiological factor in obesity as this condition can only develop when total fat oxidation is chronically lower than total exogenous fat intake. The standardization of indirect calorimetry measurements is essential for accurately tracking the relative proportion of energy expenditure derived from CHO and fat oxidation. Here we analyze literature data to show that the average fasting respiratory quotient typically shifts from approximately 0.80 to 0.90 (indicating a doubling of resting CHO oxidation) in response to a switch in dietary CHO intake (as % energy) from 30 to 60%. This underscores the importance of taking into account dietary macronutrient composition prior to indirect calorimetry studies in the interpretation of data on substrate utilization and oxidation.

References

Mar 1, 1992·The American Journal of Clinical Nutrition·Y SchutzK M Nelson
Aug 1, 1988·The American Journal of Clinical Nutrition·K J AchesonE Jéquier
Aug 1, 1972·Journal of Applied Physiology·R GilbertW Boden
Jun 1, 1980·The American Journal of Clinical Nutrition·Y Schutz, E Ravussin
Oct 1, 1994·The American Journal of Clinical Nutrition·L R RoustM D Jensen
Jul 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·R A Forse
Aug 15, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J Cooling, J Blundell
Jan 29, 2000·The American Journal of Clinical Nutrition·S R SmithG A Bray
Aug 5, 2000·European Journal of Clinical Nutrition·A H Goris, K R Westerterp
Mar 10, 2001·The American Journal of Clinical Nutrition·P H BisschopJ A Romijn
Aug 12, 2003·The British Journal of Nutrition·Christina Koutsari, Labros S Sidossis
May 8, 2004·Metabolism: Clinical and Experimental·Petr WohlTerezie Pelikánová
Aug 11, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K MinehiraL Tappy
Dec 29, 2004·Physiology & Behavior·Yves Schutz
Mar 3, 2005·The Journal of Clinical Endocrinology and Metabolism·Jukka WesterbackaHannele Yki-Järvinen
Mar 25, 2005·The British Journal of Nutrition·Manuela P G M LejeuneMargriet S Westerterp-Plantenga
Dec 13, 2006·The American Journal of Clinical Nutrition·Peter JacobsonClaude Bouchard
Apr 11, 2008·The American Journal of Clinical Nutrition·Rachel RobertsKeith N Frayn
Jun 9, 2009·Metabolism: Clinical and Experimental·Nicholas D BarwellJason M R Gill
Jan 22, 2011·The Journal of Clinical Endocrinology and Metabolism·Noud A van HerpenPatrick Schrauwen
Mar 19, 2011·Journal of Applied Physiology·Mette SkovbroFlemming Dela
Mar 13, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Katarina MelzerYves Schutz

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Citations

Nov 20, 2016·Acta Obstetricia Et Gynecologica Scandinavica·Fernando BugattoJosé L Bartha
Apr 29, 2016·Scientific Reports·Adel PezeshkiPrasanth K Chelikani
Jan 19, 2018·Journal of the International Society of Sports Nutrition·Troy PurdomChristine Mermier
Mar 4, 2020·International Journal of Molecular Sciences·Avigdor D AradFred J DiMenna
Aug 21, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Jose E Galgani, Rodrigo Fernández-Verdejo
Feb 8, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Lucas Jurado-FasoliJonatan R Ruiz
Oct 12, 2021·Molecular Nutrition & Food Research·Jingyu ZhaoYan Chen

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