PMID: 9650566Jul 3, 1998Paper

Fasting/re-feeding before initiation enhances the growth of aberrant crypt foci induced by azoxymethane in rat colon and rectum

International Journal of Cancer. Journal International Du Cancer
F PremoselliL Tessitore

Abstract

In contrast to the protective effect of chronic caloric restriction on tumor development, we have shown that fasting sustained tumor initiation in rat liver by a noninitiating dose of diethylnitrosamine. Here we investigated whether fasting had a similar favorable effect on initiation in the colorectal mucosa in 80 male F344 rats. Animals fasted for 4 days were given a single s.c. dose of azoxymethane (AOM) (20 mg/kg) on the first day of re-feeding, and rates of kinetic proliferative parameters, and development of the pre-neoplastic lesions such as aberrant crypt foci (ACF), were evaluated. Starvation before AOM treatment enhanced the growth of ACF, as shown by the significantly higher crypt multiplicity of fasted/re-fed rats as compared with fully fed rats (3.97 +/- 0.50 vs. 2.64 +/- 0.20, p < or = 0.025). This difference was associated with perturbations in cell death and cell proliferation. Fasting induced apoptosis and depressed cell division, while re-feeding had opposite effects, resulting in a higher percentage of S-phase cells at the time of AOM injection and 2 days thereafter. Starvation-induced apoptosis may represent the mitogenic stimulus to an increase in the number of cells susceptible to AOM damage, and may favor...Continue Reading

References

Jan 1, 1984·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·R A Goodlad, N A Wright
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·B Grasl-KrauppR Schulte-Hermann
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A B MillerJ Wahrendorf

❮ Previous
Next ❯

Citations

Feb 11, 2012·Science Translational Medicine·Changhan LeeValter D Longo
Mar 8, 2013·Cancer Prevention Research·Natalia A Ignatenko, Eugene W Gerner
Feb 3, 2005·Journal of Gastroenterology and Hepatology·David P Hurlstone, Simon S Cross
Jan 24, 2006·The Journal of Nutritional Biochemistry·Marc J Gunter, Michael F Leitzmann
Apr 5, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Antonina CangemiAntonio Russo
Aug 2, 2001·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M J MartinsI Azevedo
Mar 31, 2000·Cell Proliferation·L RoncucciA De Pol
Dec 10, 1999·Toxicologic Pathology·C M Fenoglio-Preiser, A Noffsinger
Oct 18, 2018·Nature Reviews. Cancer·Alessio NencioniValter D Longo
Jan 8, 2020·Nutrients·Maria CastejónAlberto Diaz-Ruiz
Jan 8, 2021·GeroScience·Sebastian Brandhorst

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis