PMID: 2512163Nov 1, 1989Paper

Fat absorption in premature infants: the effect of lard and antibiotics

European Journal of Pediatrics
H J VerkadeA Okken

Abstract

Fat absorption of an adapted cow's milk formula was studied in a randomized controlled trial involving two groups of 18 premature infants (mean gestational age +/- SD: 33.0 +/- 2.9 weeks, range 26.5-37.5 weeks). The triglyceride configuration was modified by the use of lard. This modification did not improve the absorption of fat or energy. Also no difference in serum concentrations of cholesterol and triglycerides was found. Growth velocity during the study was similar in both groups. Detailed analysis of the data revealed that in infants who received (parenterally) antibiotics (mainly ampicillin and netilmicin) a higher coefficient of fat absorption (+20%, P less than 0.01) and of energy absorption (+8%, P = 0.03) was found. Based on these results, we find no support for the use of lard in adapted cow's milk infant formulas to improve fat absorption. In studies of fat and energy absorption the effects of antibiotics have to be taken into account.

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Citations

Feb 1, 2012·Pediatric Research·Marjan Wouthuyzen-BakkerHenkjan J Verkade
Dec 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·V P CarnielliP J Sauer
Feb 14, 1998·Archives of Disease in Childhood. Fetal and Neonatal Edition·A LucasP J Lucas
Dec 13, 2006·Seminars in Fetal & Neonatal Medicine·Christian V Hulzebos, Pieter J J Sauer
Jan 1, 1997·Scandinavian Journal of Gastroenterology. Supplement·R J VonkH J Verkade
Feb 24, 2021·The Cochrane Database of Systematic Reviews·Laura PerrettaHeather L Brumberg

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