Fat body glycogen serves as a metabolic safeguard for the maintenance of sugar levels in Drosophila

Development
Takayuki YamadaTakashi Nishimura

Abstract

Adapting to changes in food availability is a central challenge for survival. Glucose is an important resource for energy production, and therefore many organisms synthesize and retain sugar storage molecules. In insects, glucose is stored in two different forms: the disaccharide trehalose and the branched polymer glycogen. Glycogen is synthesized and stored in several tissues, including in muscle and the fat body. Despite the major role of the fat body as a center for energy metabolism, the importance of its glycogen content remains unclear. Here, we show that glycogen metabolism is regulated in a tissue-specific manner under starvation conditions in the fruit fly Drosophila The mobilization of fat body glycogen in larvae is independent of Adipokinetic hormone (Akh, the glucagon homolog) but is regulated by sugar availability in a tissue-autonomous manner. Fat body glycogen plays a crucial role in the maintenance of circulating sugars, including trehalose, under fasting conditions. These results demonstrate the importance of fat body glycogen as a metabolic safeguard in Drosophila.

References

May 15, 1996·Experientia·A BeckerG Wegener
Apr 29, 1998·Annual Review of Physiology·J H CroweL M Crowe
Feb 17, 2000·Annals of the New York Academy of Sciences·R C OudejansD J van der Horst
Mar 11, 2003·Glycobiology·Alan D ElbeinDavid Carroll
Dec 17, 2003·Journal of Neurochemistry·John E ZimmermanAllan I Pack
Aug 7, 2004·Developmental Cell·Ryan C ScottThomas P Neufeld
Dec 1, 2006·Nature·Eugenio GutierrezAlex P Gould
Dec 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Walter F EanesChen-Tseh Zhu
May 10, 2007·PLoS Biology·Sebastian GrönkeRonald P Kühnlein
Oct 3, 2007·Cell Metabolism·Keith D Baker, Carl S Thummel
Nov 13, 2007·Nature·Pierre Leopold, Norbert Perrimon
Sep 23, 2008·The Journal of Experimental Biology·K N BharuchaS L Zipursky
Sep 4, 2009·Annual Review of Entomology·Estela L Arrese, Jose L Soulages
Dec 17, 2009·The Biochemical Journal·Aurelio A Teleman
Nov 3, 2010·Cell Metabolism·Michale BouskilaKei Sakamoto
Nov 19, 2010·Molecular Endocrinology·Anne-Françoise RuaudCarl S Thummel
May 7, 2011·IUBMB Life·Richard Cornette, Takahiro Kikawada
Jan 18, 2012·The Biochemical Journal·Peter J RoachVincent S Tagliabracci
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Naoki OkamotoTakashi Nishimura
May 3, 2012·EMBO Molecular Medicine·Jordi DuranJoan J Guinovart
Jan 12, 2013·Genes & Development·Naoki OkamotoTakashi Nishimura
Nov 23, 2013·PLoS Biology·Jonathan ZirinNorbert Perrimon
Feb 27, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Isabel SaezJoan J Guinovart
Mar 19, 2014·Methods : a Companion to Methods in Enzymology·Jason M TennessenCarl S Thummel
Jul 26, 2014·Aging Cell·Christopher SinadinosJoan J Guinovart
Nov 28, 2014·Glycobiology·Ekta ShuklaSushama M Gaikwad
Dec 3, 2014·The Journal of Biological Chemistry·Hiroko MatsudaTakashi Nishimura
Feb 19, 2015·PLoS Genetics·Damien GarridoJacques Montagne
Feb 19, 2015·PLoS Genetics·Jonathan ZirinNorbert Perrimon
Aug 4, 2015·Cell Metabolism·Anne VolkenhoffStefanie Schirmeier
Aug 16, 2015·Genetics·Martina GálikováRonald P Kühnlein
Sep 8, 2015·Molecular Aspects of Medicine·Jordi Duran, Joan J Guinovart
Apr 8, 2016·Disease Models & Mechanisms·Ronald W Alfa, Seung K Kim
Oct 13, 2016·Annual Review of Genetics·Ilia A Droujinine, Norbert Perrimon
Dec 8, 2016·Trends in Endocrinology and Metabolism : TEM·Wen-Bin Alfred ChngBruno Lemaitre
Feb 27, 2017·Neurobiology of Disease·Astrid WeilerStefanie Schirmeier

❮ Previous
Next ❯

Citations

Jun 30, 2018·International Journal of Molecular Sciences·Martina Gáliková, Peter Klepsatel
Mar 29, 2019·Development·Takayuki YamadaTakashi Nishimura
Aug 6, 2019·Wiley Interdisciplinary Reviews. Developmental Biology·Muhammad AhmadNorbert Perrimon
Sep 11, 2018·Frontiers in Physiology·Uliana V SemaniukOleh Lushchak
May 26, 2020·Cellular and Molecular Life Sciences : CMLS·Takashi KoyamaKim Rewitz
Jan 24, 2021·Scientific Reports·Surya BanerjeeJennifer Curtiss
Nov 17, 2020·Frontiers in Physiology·Heidi Bretscher, Michael B O'Connor
Nov 27, 2020·Toxicology and Industrial Health·Akanksha RajNamita Agrawal
Apr 19, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jamiyu Ayodeji SaliuAderopo Akinnubi
Apr 26, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Sofía SanhuezaPaulina Ormazabal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved