Fat cell-secreted adiponectin mediates physical exercise-induced hippocampal neurogenesis: an alternative anti-depressive treatment?

Neural Regeneration Research
Suk Yu YauKwok-Fai So

Abstract

Psychological depression is drawing accumulating attention nowadays, due to the skyrocketing incidence worldwide and the enormous burdens it incurs. Physical exercise has been long recognized for its therapeutic effects on depressive disorders, although knowledge of the underlying mechanisms remains limited. Suppressed hippocampal neurogenesis in adult brains has been regarded, at least partly, contributive to depression, whereas physical exercise that restores neurogenesis accordingly exerts the anti-depressive action. Several recent publications have suggested the potential role of adiponectin, a protein hormone secreted by peripheral mature adipocytes, in mediating physical exercise-triggered enhancement of hippocampal neurogenesis and alleviation of depression. Here, we briefly review these novel findings and discuss the possibility of counteracting depression by modulating adiponectin signaling in the hippocampus with interventions including physical exercise and administration of pharmacological agents.

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Oct 22, 2014·Proceedings of the National Academy of Sciences of the United States of America·Suk Yu YauKwok-Fai So

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Citations

May 30, 2019·Molecular Neurobiology·Douglas Affonso FormoloSuk-Yu Yau
Jan 3, 2019·Sports Medicine and Arthroscopy Review·John Onate
May 13, 2020·Neural Regeneration Research·Thais Ceresér VilelaRicardo Aurino de Pinho
Jul 30, 2019·Scandinavian Journal of Medicine & Science in Sports·Tiago Alencar de LimaErik Artur Cortinhas-Alves
Jan 9, 2021·Frontiers in Aging Neuroscience·Yaqiang LiuChaoyue Meng
Nov 25, 2020·Neural Regeneration Research·Mariam RizkZhi Zhang

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