Fat distribution and plasminogen activator inhibitor activity in nondiabetic obese women

Metabolism: Clinical and Experimental
P VagueC Atlan

Abstract

Epidemiologic data strongly suggest that upper distribution of body fat and high plasminogen activator inhibitor (PAI) activity are risk factors for cardiovascular disease. Therefore, a link between these two parameters was evaluated by studying 51 menstrually active nondiabetic obese women. In this group positive correlations were observed between body mass index (BMI), waist to hip circumference ratio (W/H ratio, which estimates body fat distribution), plasma insulin, and PAI activity. In addition, plasma triglycerides were related to the W/H ratio and insulin and PAI activity. Partial correlations revealed that BMI was independently and solely related to W/H ratio, which was also independently related to plasma insulin, which in turn related to PAI activity. These results suggest that upper body fat distribution acts as a risk factor of cardiovascular disease through its association with high PAI activity.

Citations

Nov 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·Y LatronI Juhan-Vague
Mar 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·R P GrayJ S Yudkin
Jan 1, 1996·Breast Cancer Research and Treatment·B A Stoll
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·F SamadD J Loskutoff
May 14, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·P E MorangeI Juhan-Vague
Jun 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·A MavriB R Binder
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·F SamadD J Loskutoff
Jan 18, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M P SolanoR B Goldberg
May 15, 2003·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·I PolacT Pertynski
Oct 29, 2003·Journal of Pediatric Gastroenterology and Nutrition·Anne Marfaing-KokaPhilippe Labrune
Sep 25, 2004·Medicinal Research Reviews·Josep M ArgilésFrancisco J López-Soriano
Feb 24, 2007·Journal of Endocrinological Investigation·F OrioA Colao
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Julie P SutherlandRobert H Eckel
Jul 20, 2010·Journal of Thrombosis and Thrombolysis·David KarasekDalibor Novotny
Apr 11, 2018·Frontiers in Physiology·Rashmi SupriyaParco M Siu
Mar 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·M CigoliniG De Sandre
Aug 25, 2005·Experimental Physiology·Onanong KulaputanaJames M Hagberg
Sep 22, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Barbara Salobir, Miso Sabovic
Jan 29, 2005·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Finn Edler von EybenRie von Eyben
Jun 16, 2006·Human Reproduction Update·Gabriella G GosmanRichard S Legro
Dec 9, 2010·European Journal of Pediatrics·Assimina Galli-TsinopoulouGeorge Varlamis
May 17, 2017·Aesthetic Surgery Journal·Stephen A Schendel
Apr 15, 1997·Annals of the New York Academy of Sciences·F SamadD Loskutoff
May 11, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·N TadokoroY Saito
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·I Mertens, L F Van Gaal
Oct 30, 2001·The Proceedings of the Nutrition Society·N J MutchN A Booth
Nov 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·Y BahruM Walker
Jun 27, 2000·Diabetes/metabolism Research and Reviews·J P BastardB Hainque
Aug 26, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Marie-Christine Alessi, Irène Juhan-Vague
Oct 31, 2014·Expert Review of Cardiovascular Therapy·Yu Kataoka, Stephen J Nicholls
May 16, 2017·Metabolic Syndrome and Related Disorders·Omar BayomyGail K Adler
Jul 3, 2013·Oxidative Medicine and Cellular Longevity·Ivana ZagottaPamela Fischer-Posovszky
Sep 1, 1996·Journal of Clinical Epidemiology·H S KahnD Arensberg
Feb 9, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·J P Bastard, L Piéroni
Jul 1, 1993·Experimental Gerontology·L I KatzelA P Goldberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Song-Ming DuYong-Hua Hu
Arquivos brasileiros de cardiologia
Fabiane Aparecida Canaan RezendeCarlos Roberto de Carvalho
Journal of the European Academy of Dermatology and Venereology : JEADV
S KumarA A Qureshi
© 2022 Meta ULC. All rights reserved