Fat embolism and related effects during reamed and unreamed intramedullary nailing in a pig model

Journal of Orthopaedic Trauma
M ButtaroL Piñeiro

Abstract

To determine whether reamed or unreamed femoral intramedullary nailing is more adverse to pulmonary function, the authors compared three populations of healthy pigs, analyzing the biochemical and hemodynamic effects related to fat embolism. Likewise, the authors histologically evaluated the presence of bone marrow fat embolism in lungs, heart, kidney, brain, and retina. Randomized, experimental model. Laboratory. Twenty-five male Duroc Jersey adult healthy pigs divided in three groups. Reamed and unreamed intramedullary nailing. Biochemical, hemodinamical, and histologic analysis. In the first group of ten pigs, a reamed nail was inserted; in the second group of ten specimens, the authors placed an unreamed nail; and in the third group of five animals (control), only the surgical approach was made without opening the medullary cavity. The authors did not find statistically significant differences in pulmonary function between the reamed and unreamed group in the hemodynamic, biochemical, and histopathologic parameters evaluated. The histologic analysis of the lung tissue revealed a statistically significant difference between the nailed groups and the control (P < 0.04). In this animal model, the results indicate that pulmonary...Continue Reading

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Citations

Jan 23, 2010·The Journal of Trauma·Meri S KarankoR Eero A Gullichsen
May 19, 2012·BMJ Case Reports·Jason Pui Yin CheungMichael To
Oct 30, 2007·Acta Orthopaedica·Mark T Clayer, Xiaodong Tang
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Sep 23, 2006·Injury·Peter V GiannoudisHans-Christoph Pape
Nov 2, 2005·Injury·D Bose, N C Tejwani
Nov 6, 2003·Clinical Orthopaedics and Related Research·Peter F M Choong
May 24, 2014·The Journal of Trauma and Acute Care Surgery·Frank HildebrandHans-Christoph Pape
Jan 6, 2010·The Journal of Bone and Joint Surgery. American Volume·Michael BlanksteinEmil H Schemitsch
Feb 6, 2007·The Journal of the American Academy of Orthopaedic Surgeons·Matthew R BongKenneth A Egol
Nov 14, 2007·The Journal of Bone and Joint Surgery. British Volume·T O HammerC A Müller
Apr 21, 2021·Scientific Reports·Birte WeberMiriam Kalbitz

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