Fat-Free Mass and Skeletal Muscle Mass Five Years After Bariatric Surgery.

Obesity
Lance DavidsonDympna Gallagher

Abstract

This study investigated changes in fat-free mass (FFM) and skeletal muscle 5 years after surgery in participants from the Longitudinal Assessment of Bariatric Surgery-2 trial. A three-compartment model assessed FFM, and whole-body magnetic resonance imaging (MRI) quantified skeletal muscle mass prior to surgery (T0) and 1 year (T1), 2 years (T2), and 5 years (T5) postoperatively in 93 patients (85% female; 68% Caucasian; age 44.2 ± 11.6 years) who underwent gastric bypass (RYGB), sleeve gastrectomy, or adjustable gastric band. Repeated-measures mixed models were used to analyze the data. Significant weight loss occurred across all surgical groups in females from T0 to T1. FFM loss from T0 to T1 was greater after RYGB (mean ± SE: -6.9 ± 0.6 kg) than adjustable gastric band (-3.5 ± 1.4 kg; P < 0.05). Females with RYGB continued to lose FFM (-3.3 ± 0.7 kg; P < 0.001) from T1 to T5. A subset of males and females with RYGB and MRI-measured skeletal muscle showed similar initial FFM loss while maintaining FFM and skeletal muscle from T1 to T5. Between 1 and 5 years following common bariatric procedures, FFM and skeletal muscle are maintained or decrease minimally. The changes observed in FFM and muscle during the follow-up phase may ...Continue Reading

Associated Clinical Trials

Apr 25, 2007·Steven Belle

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Citations

Oct 23, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Bryan C Jiang, Dennis T Villareal
Oct 12, 2019·Obesity Surgery·Kristen A OuelletteLance E Davidson
May 27, 2020·Current Obesity Reports·Julie M ParrottMary O'Kane
Jun 18, 2020·Frontiers in Endocrinology·Karl J Neff, Carel W Le Roux
May 18, 2020·Obesity Surgery·Malou A H NuijtenMaria T E Hopman
Mar 4, 2020·Obesity Surgery·Enrico PinottiLuigi Angrisani
Aug 11, 2018·Obesity Surgery·Zubaidah Nor Hanipah, Philip R Schauer
Aug 11, 2020·Journal of the Endocrine Society·Fatimo BiobakuParesh Dandona
Jun 17, 2020·Nutrition·Geir BjørklundDaniel-Ovidiu Costea
Mar 16, 2021·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Vicente J CogolloRaul J Rosenthal
Oct 25, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Neda HaghighatMasoud Amini
Nov 21, 2021·Obesity Surgery·Carolina Hunger Malek-ZadehCarla Barbosa Nonino

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Methods Mentioned

BETA
gastric bypass
X-ray

Software Mentioned

SliceOmatic
SAS
Tomovision

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