Fat mass- and obesity-associated gene Fto affects the dietary response in mouse white adipose tissue

Scientific Reports
Justiina RonkainenTuire Salonurmi

Abstract

Common variants of human fat mass- and obesity-associated gene Fto have been linked with higher body mass index, but the biological explanation for the link has remained obscure. Recent findings suggest that these variants affect the homeobox protein IRX3. Here we report that FTO has a role in white adipose tissue which modifies its response to high-fat feeding. Wild type and Fto-deficient mice were exposed to standard or high-fat diet for 16 weeks after which metabolism, behavior and white adipose tissue morphology were analyzed together with adipokine levels and relative expression of genes regulating white adipose tissue adipogenesis and Irx3. Our results indicate that Fto deficiency increases the expression of genes related to adipogenesis preventing adipocytes from becoming hypertrophic after high-fat diet. In addition, we report a novel finding of increased Irx3 expression in Fto-deficient mice after high-fat feeding indicating a complex link between FTO, IRX3 and fat metabolism.

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Citations

Sep 22, 2015·International Journal of Molecular Sciences·Jung-Chun Lin
Jan 21, 2016·International Journal of Endocrinology·Myrte Merkestein, Dyan Sellayah
Oct 3, 2015·Molecular and Cellular Endocrinology·Camilla H SandholtTorben Hansen
Nov 10, 2016·International Journal of Molecular Sciences·Justiina RonkainenTuire Salonurmi
Nov 12, 2019·Pflügers Archiv : European journal of physiology·Fang HuChengzhi Lu
Aug 28, 2020·Lipids in Health and Disease·Mahsa MehrdadMohammad Hassan Eftekhari
Sep 5, 2019·Frontiers in Cardiovascular Medicine·Esam S B SalemTakahisa Nakamura
Jun 6, 2020·Cellular and Molecular Neurobiology·Huan ZhangYue-Sheng Long
Apr 11, 2018·Frontiers in Cell and Developmental Biology·Qifan ZhuRamiro Alberio
Oct 9, 2020·Molecular and Cellular Biochemistry·Suresh C TyagiMahavir Singh
Aug 22, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Farhad VahidSayed Hossein Davoodi
Sep 8, 2021·Journal of Cellular and Molecular Medicine·Maryam GholamalizadehSeyed Alireza Mosavi Jarrahi
Oct 3, 2015·Genome Research·William L Lowe, Timothy E Reddy

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Methods Mentioned

BETA
PCR
transgenic

Software Mentioned

SPSS
Fiji

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