Fat pad-specific compensatory mass increases after varying degrees of lipectomy in Siberian hamsters

The American Journal of Physiology
M M Mauer, T J Bartness

Abstract

Long day-housed Siberian hamsters show compensatory mass increases in inguinal (I) white adipose tissue (WAT) after epididymal WAT pad (EWAT) removal (x) but do not increase EWAT mass after IWATx. This study tested whether EWAT is specifically unresponsive to IWATx or whether EWAT lacks responsiveness to body fat deficits in general. We also tested whether the compensatory mass increases that occur after side-specific body fat removal are unilateral or bilateral. Therefore EWAT and/or IWAT was removed unilaterally or bilaterally. The compensatory changes in WAT mass by the intact fat pads were measured 12 wk later. EWAT did not compensate for removal of its contralateral mate. Retroperitoneal WAT and IWAT showed greater compensatory mass increases ipsilateral to the side of fat pad removal when EWAT or IWAT pads were removed unilaterally but not after removal of larger amounts of body fat. These results suggest the following: 1) in general, the greater the lipectomy-induced lipid deficit, the greater is the relative fat pad mass compensation; 2) the restoration of body fat content after lipectomy may involve mechanisms that can detect the side of the lipid deficit and enhance fat deposition on this side; and 3) EWAT does not sh...Continue Reading

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Citations

Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·G E Demas, T J Bartness
Oct 4, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eva L Lacy, Timothy J Bartness
Jun 10, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Timothy J BartnessB J Teubner
Nov 16, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Megan E Dailey, Timothy J Bartness
Apr 2, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eva L Lacy, Timothy J Bartness
Feb 20, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew J PaulBrian J Prendergast
Apr 30, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Haifei Shi, Timothy J Bartness

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