Fatal acute granulomatous pulmonary aspergillosis in a healthy subject after inhalation of vegetal dust

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
E BatardP Germaud

Abstract

A previously healthy 28-year-old man presented a few hours after inhalation of vegetal dust with acute bilateral community-acquired pneumonia, which caused death in 10 days despite treatment with broad-spectrum antibiotics, intravenous amphotericin B, inotropic support, and mechanical ventilation. A postmortem lung biopsy indicated miliary granulomatous pulmonary aspergillosis. Six similar previously published cases of acute granulomatous pulmonary aspergillosis are reviewed. This entity in adulthood may reveal a defect in neutrophil or macrophage function, such as late-onset chronic granulomatous disease.

Citations

Aug 23, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sophia SiddiquiSteven M Holland
Sep 30, 2006·Scandinavian Journal of Infectious Diseases·Maiken Cavling ArendrupDavid W Denning
Nov 19, 2015·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Vikas PilaniyaAshok Shah
Jun 26, 2007·Pediatrics International : Official Journal of the Japan Pediatric Society·Bülent KarapinarFadil Vardar

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