Fatal drug concentrations in body fluids and tissue samples are presented for more than 200 drugs and chemicals of toxicologic interest. Additionally, a reference list is added with more than 600 original papers concerning intoxications with a lethal outcome. The data can be helpful for the interpretation and plausibility control in own cases of intoxication. However, they should be used with caution, because use of drug data without sufficient knowledge about the patient or victim, the circumstances of the case, and about toxicokinetics and toxicodynamics might give a wrong interpretation in a special case.
Propoxyphene and norpropoxyphene tissue concentrations in fatalities associated with propoxyphene hydrochloride and propoxyphene napsylate
Fatal combined anileridine-pethidine poisoning. A gas chromatography, thin layer chromatography and mass spectrometry investigation
Measurement of digitalis-glycoside levels in ocular tissues: a way to improve postmortem diagnosis of lethal digitalis-glycoside poisoning? I. Digoxin
Two fatalities from ingestion of acetonitrile: limited specificity of analysis by headspace gas chromatography
Gas chromatographic-mass spectrometric analysis of buflomedil hydrochloride in biological samples after acute intoxication
Chlormezanone plasma and blood levels in patients after single and repeated oral doses and after suicidal drug overdose
Gas chromatographic identification and quantification of hydroxyzine: application in a fatal self-poisoning
The importance of blood collection site for the determination of basic drugs: a case with fluoxetine and diphenhydramine overdose
A simple gas chromatographic identification and determination of 11 CNS stimulants in biological samples. Application on a fatality involving phendimetrazine
Gas chromatographic analysis of verapamil and norverapamil in post mortem specimens using a 530-micron fused-silica column with nitrogen-phosphorus detection
Death associated with inadvertent hydrocodone overdose in a child with a respiratory tract infection
Two tricyclic antidepressant poisonings: levels of amitriptyline, nortriptyline and desipramine in post-mortem biological samples
Paraquat (gramoxone) poisoning in south-west Hungary, 1977-1984. Toxicological and histopathological aspects of group intoxication cases
Forensic toxicologic analysis of methamphetamine and amphetamine in body materials by gas chromatography/mass spectrometry
Pentachlorophenol intoxication: report of a fatal case, with comments on the clinical course and pathologic anatomy
Distribution of amitriptyline and nortriptyline in fatal amitriptyline intoxications with different survival times
Fatal intoxication with chlorpromazine with special regard to the influence of putrefaction on its toxicological analysis
Interpretation of blood glutethimide, meprobamate, and methyprylon concentrations in nonfatal and fatal intoxications involving a single drug
Two cases of death involving dicyclomine in infants. Measurement of therapeutic and toxic concentrations in blood
Postmortem blood concentrations of parent tricyclic antidepressant (TCA) drugs in 11 cases of suicide
CI-mass fragmentographic analysis of methamphetamine and amphetamine in human autopsy tissues after acute methamphetamine poisoning
Blood and tissue concentrations of tricyclic antidepressant drugs in post mortem cases: literature survey and a study of forty deaths
A suicide by pancuronium bromide injection: evaluation of the fluorometric determination of pancuronium in postmortem blood, serum and urine
Interpretation of blood and tissue concentrations in fatal self-ingested overdose involving amitriptyline: an update (1978-1979)
Clinical findings, elimination pharmacokinetics, and tissue drug concentrations following a fatal amitriptyline intoxication
Postmortem changes in blood tranylcypromine concentration: competing redistribution and degradation effects
Coin-operated dry cleaning machines may be responsible for acute tetrachloroethylene poisoning: report of 26 cases including one death
One fatal and one nonfatal intoxication with tranylcypromine. Absence of amphetamines as metabolites
High-performance liquid chromatography of alprazolam in postmortem blood using solid-phase extraction
Distribution of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) stereoisomers in a fatal poisoning
Concentrations of heroin, 06-monoacetylmorphine, and morphine in a lethal case following an oral heroin overdose
Moclobemide fatalities: report of two cases and analytical determinations by GC-MS and HPLC-PDA after solid-phase extraction
Morphine, morphine-3-glucuronide, morphine-6-glucuronide, and 6-monoacetylmorphine determined by means of atmospheric pressure chemical ionization-mass spectrometry-liquid chromatography in body fluids of heroin victims
Postmortem distribution of dihydrocodeine and metabolites in a fatal case of dihydrocodeine intoxication
Quantitative determination of paraquat in a fatal intoxication by HPLC-DAD following chemical reduction with sodium borohydride
Analytical method for the determination of strychnine in tissues by gas chromatography/mass spectrometry: two case reports
Rapid analysis of halothane in biological samples using headspace solid-phase microextraction and gas chromatography-mass spectrometry--a case of a double homicide
Determination of formic acid tissue and fluid concentrations in three fatalities due to methanol poisoning
Fatal 4-MTA intoxication: development of a liquid chromatographic-tandem mass spectrometric assay for multiple matrices
Distribution study of 3,4-methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine in a fatal overdose
Oxycontin: the concept of a "ghost pill" and the postmortem tissue distribution of oxycodone in 36 cases
Suicide by injection of a veterinarian barbiturate euthanasia agent: report of a case and toxicological analysis
Inhibition of G protein-activated inwardly rectifying K+ channels by different classes of antidepressants
Liver and peripheral blood concentration ratio (L/P) as a marker of postmortem drug redistribution: a literature review
Gas chromatography-tandem mass spectrometry assay for the quantification of four benzodiazepines and citalopram in eleven postmortem rabbit fluids and tissues, with application to animal and human samples
Quality assessment of fluoxetine and fluvoxamine pharmaceutical formulations purchased in different countries or via the Internet by 19F and 2D DOSY 1H NMR
Determination of verapamil hydrochloride with 12-tungstophosphoric acid by resonance Rayleigh scattering method coupled to flow injection system
Optimizing the extraction, separation and quantification of tricyclic antidepressant drugs in human plasma with CE-ESI-TOF-MS using cationic-coated capillaries
Direct determination of verapamil in urine and serum samples by micellar liquid chromatography and fluorescence detection
A rapid and accurate UPLC/MS/MS method for the simultaneous determination of zolpidem and its main metabolites in biological fluids and its application in a forensic context
A new model for using quantitative urine testing as a diagnostic tool for oxycodone treatment and compliance
Development and Validation of a GC-MS Method for the Detection and Quantification of Clotiapine in Blood and Urine Specimens and Application to a Postmortem Case
Bisorbicillinoids produced by the fungus Trichoderma citrinoviride affect feeding preference of the aphid Schizaphis graminum
Precise measurement of (1)H 90 degrees pulse in solid-state NMR spectroscopy for complex and heterogeneous molecular systems
Effect of triphenylphosphonium moiety on spatial structure and biointeractions of stereochemical variants of YRFK motif
Determination of benzodiazepines in blood and in dried blood spots collected from post-mortem samples and evaluation of the stability over a three-month period
Mercuric chloride poisoning: symptoms, analysis, therapies, and autoptic findings. A review of the literature
Suicide by multidrug ingestion: hypothesis on the role played by the self-administration of activated charcoal
Modern scientific evidence pertaining to criminal investigations in the Chosun dynasty era (1392-1897 A.C.E.) in Korea
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
Synthetic Genetic Array Analysis
Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.
Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.
Neural Activity: Imaging
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Chronic Fatigue Syndrome
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Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.
Cell Atlas of the Human Eye
Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.
Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.
STING Receptor Agonists
Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.