Fatal cases of Citrobacter freundii septicemia and encephalitis in sheep

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Huisheng LiuQiao Xue

Abstract

Citrobacter freundii is considered a ubiquitous organism and an opportunistic pathogen. Reports of C. freundii-associated disease in mammals have been very limited. We report an outbreak of C. freundii septicemia and encephalitis in sheep, with a high mortality rate; 13 adult sheep were found dead over a 6-d period on a farm in central China that housed ~1,370 sheep. Three animals were autopsied and showed septicemia, congestion of meningeal vessels, and pleural effusion. C. freundii was isolated in abundance in pure culture from 19 of 21 organs. All 3 C. freundii isolates had similar antimicrobial resistance phenotypes for 10 of the 11 agents tested, and were sensitive to 8 of the 11 agents. We reproduced C. freundii infection in sheep experimentally by oral or subcutaneous inoculation routes, and recovered the challenge organism from all of the experimentally infected sheep. Intramuscular injection of enrofloxacin protected sheep against an otherwise fatal challenge. Our results suggest that C. freundii played a major role in this disease outbreak.

References

Oct 26, 1999·The Pediatric Infectious Disease Journal·M A Gill, G E Schutze
Oct 9, 2003·Journal of Clinical Microbiology·Iruka N OkekeJames B Kaper
Nov 5, 2010·Journal of Avian Medicine and Surgery·Silvia Neri Godoy, Eliana Reiko Matushima
Nov 16, 2010·International Journal of Antimicrobial Agents·Christa EwersMirjam Grobbel
Jun 4, 2011·Toxicon : Official Journal of the International Society on Toxinology·Marta O DomingosKatia C Barbaro
Nov 22, 2011·Journal of Wildlife Diseases·Antonio FernándezManuel Arbelo
Apr 18, 2013·Pediatrics and Neonatology·Nishad PlakkalHarish Amin
Jun 19, 2013·Veterinary Microbiology·Cecilie K KjelstrupTrine M L'Abée-Lund

❮ Previous
Next ❯

Citations

Dec 8, 2021·Transboundary and Emerging Diseases·Herbert WeissenböckMartin Beer

❮ Previous
Next ❯

Datasets Mentioned

BETA
KP224274
AB244300.1
AB244451.1
AB548826.1
AB548577.1

Methods Mentioned

BETA
PCR

Software Mentioned

BLAST

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Anales de medicina interna : organo oficial de la Sociedad Española de Medicina Interna
V Meseguer RuizL Sáez Mendez
The Veterinary Record
V A de la Puente-RedondoE F Rodríguez-Ferri
© 2022 Meta ULC. All rights reserved