Fatal cases of human infection with avian influenza A (H7N9) virus in Shanghai, China in 2013

Bioscience Trends
Yinzhong ShenZhiyong Zhang

Abstract

We retrospectively reviewed the medical records of 17 fatal H7N9 cases in Shanghai in 2013, analyzed clinical variables and described their clinical and epidemiologic characteristics. The median age was 73 years, and 82.4% had underlying medical conditions. The most frequent symptoms were fever (100%), followed by productive cough (47.1%) and dry cough (35.5%). Thirteen (76.5%) patients had dyspnea or respiratory distress, five (29.4%) had shock, and four (23.5%) had acute kidney injury. Seventeen (100.0%) patients had lymphopenia. Involvement of both lungs was found by chest radiography in 14 (82.4%) patients at presentation. Fifteen (88.2%) patients were hospitalized. The median times from illness onset to hospitalization and to diagnosis confirmation were both six days. Eleven (64.7%) patients were admitted to the intensive care unit. Sixteen (94.1%) patients were treated with oseltamivir. The median time from illness onset to oseltamivir treatment was six days. Among six patients for whom the duration of viral shedding was available, the median duration of viral shedding after oseltamivir treatment was 17 days. The median time from illness onset to death was 11 days. Refractory hypoxemia accounted for most deaths. The clini...Continue Reading

References

Feb 27, 2004·The New England Journal of Medicine·Tinh Hien TranUNKNOWN World Health Organization International Avian Influenza Investigative Team
Mar 10, 2011·The Journal of Antimicrobial Chemotherapy·Alejandro RodríguezUNKNOWN H1N1 SEMICYUC Working Group
Mar 19, 2011·Chest·Diego ViasusUNKNOWN Novel Influenza A(H1N1) Study Group of the Spanish Network for Research in Infectious Diseases (REIPI)
Apr 13, 2013·The New England Journal of Medicine·Rongbao GaoYuelong Shu
Apr 13, 2013·The New England Journal of Medicine·Timothy M Uyeki, Nancy J Cox
Apr 26, 2013·The New England Journal of Medicine·Qun LiZijian Feng
May 24, 2013·The New England Journal of Medicine·Hai-Nv GaoLan-Juan Li

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