Jun 15, 1977

Fatal cerebral apoplexy as the first manifestation of immature infantile leukemia (author's transl)

Acta Neuropathologica
K O SchmidH Rosegger

Abstract

Among 93 clinical cases of mature and immature leukemia among children in the last 10 years only 3 showed massive cerebral hemorrhage as the first manifestation. The children--aged 5 3/12 yr., m., 2 1/12 yr., f., and 10 3/12 yr., m. died within 40, 48 and 7 h, respectively. Characteristically, an extreme hyperleukocytosis of immature cells with 8999000, 585000, and 360000 cells/mm3, respectively was found. Morphologically the quantitatively varying occurrence of blasts in veins and arteries, basically of hemodynamic origin, is notable, while locally pronounced variations in the venous involvement apparently are strongly dependent upon endovasal growth periods of the blasts. The blasts penetrated extravasal areas not only via passive but also via active migration. The mainly round to oval shape of the perivascular infiltrates of blasts is determined especially by the Virchow-Robins' spaces. The abscence of growth disrupting hemodynamics and texture structures in the unhindered areas of the cerebral ventricle system and retinal detachement favors the formation of leukemic nodules. Neurological symptoms accompanying a high blast count point to a diagnosis of intracerebral hemorrhage.

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Retinal Detachment
Brain
Nodulation
Structure of virchow-Robin Space
Blast Cell
Acute Disease
Thyroid Nodule
Cerebral Hemorrhage
Structure
Cerebral Hemisphere Hemorrhage

About this Paper

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

The Tohoku Journal of Experimental Medicine
T TakahashiG Takada
Journal of the Formosan Medical Association = Taiwan Yi Zhi
Yao-Kuang WuYing-Huang Tsai
The Journal of Emergency Medicine
Joseph R Shiber, Robert E Fines
© 2020 Meta ULC. All rights reserved