Fatal CMV pneumonia associated with steroid therapy after autologous transplantation in patients previously treated with fludarabine

Bone Marrow Transplantation
A GriggJ Szer

Abstract

Fludarabine has been associated with an increased risk of opportunistic infections, possibly related to the induction of profound CD4+ lymphopenia. We observed two cases of cytomegalovirus pneumonia (CMV-IP) in a total of nine patients over a 5-year period who had previously received fludarabine and who proceeded to autografting. Both patients also received steroids post-transplant. CMV-IP was observed in one of 104 other autograft recipients over this time who had not received prior fludarabine. This observation suggests that the combination of fludarabine pre-transplant and steroids post-transplant may increase the risk of invasive CMV disease in autograft recipients.

Citations

Oct 29, 2000·British Journal of Haematology·D J Ramsey, S A Schey
Oct 2, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John A Zaia
Sep 27, 2003·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Annunziata MannaPaolo Pronzato
Sep 11, 2007·Infectious Disease Clinics of North America·Gilbert G Fareau, Rena Vassilopoulou-Sellin
Jul 13, 2001·Infectious Disease Clinics of North America·N C KleinB A Cunha

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