Fatal diffuse alveolar damage complicating acute myeloid leukemia with abnormal eosinophils and trisomy X

Annals of Hematology
T S K WanS K Ma

Abstract

We describe a case of acute myeloid leukemia (AML) with abnormal eosinophils in a 44-year-old Chinese woman that was complicated by diffuse alveolar damage (DAD) and pulmonary hemorrhage (PH) shortly after induction chemotherapy. Cytogenetic study of bone marrow cells at diagnosis showed a rare aberration of trisomy X (+X) as the sole acquired karyotypic abnormality. We speculate that tissue damage by cellular constituents of the abnormal eosinophils that were released on cell lysis after chemotherapy might be etiologically linked to the occurrence of fatal pulmonary complications.

Citations

Jun 30, 2012·Revue des maladies respiratoires·F VincentUNKNOWN Groupe de recherche en réanimation respiratoire en onco-hématologie
Oct 3, 2006·Cancer Genetics and Cytogenetics·Hiroto KanekoYasuo Ohkawara
Jul 5, 2013·Annals of Laboratory Medicine·Mi-Ae JangChul Won Jung
Nov 5, 2014·Annals of Laboratory Medicine·Thomas S K Wan
Jun 9, 2020·International Journal of Hematology·Minoru Kanaya, Takeshi Kondo

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