PMID: 6979250May 1, 1982Paper

Fatal disseminated aspergillosis in a previously well young adult with cystic fibrosis

The American Journal of the Medical Sciences
T L GuidottiD U Escaro

Abstract

Patients with cystic fibrosis (CF) are often colonized by Aspergillus species in their respiratory tract but rarely develop infection with this fungus. A young woman with CF who had mild pulmonary involvement and who was in good health developed a fulminant illness presenting as brainstem infarction and simulating thrombotic thrombocytopenic purpura. At necropsy she was found to have disseminated aspergillosis and a depletion of lymphocytes in the thymus-independent zone of splenic follicles. This unique case may be an unusual expression of abnormal T-cell function and the paradoxical histopathologic findings may relate to the disturbance in humoral immunity in children with CF recently described by Matthews et al.

References

Aug 1, 1978·Archives of Disease in Childhood·M W TurnerC R Stokes
Mar 1, 1973·The Journal of Pediatrics·L M TaussigP A Di Sant'Agnese
Mar 1, 1970·Medicine·R C YoungV T DeVita
Nov 1, 1970·Thorax·W P KennedyW Blyth

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Citations

Feb 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H SchønheyderC Koch
Apr 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·N Khardori
May 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G P Bodey, S Vartivarian
Sep 9, 2010·The Pediatric Infectious Disease Journal·Joanna MassamValerie Waters
Jan 1, 1987·Scandinavian Journal of Infectious Diseases. Supplementum·H Schønheyder
Nov 19, 2015·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Kirti GuptaArunaloke Chakrabarti
Aug 19, 2011·American Journal of Hematology·Kristina K BoothJames N George

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Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.