PMID: 8996421Jan 11, 1997Paper

Fatal encephalitis due to novel paramyxovirus transmitted from horses

Lancet
J D O'SullivanJ Bradfield

Abstract

In September, 1994, an outbreak of severe respiratory disease affected 18 horses, their trainer, and a stablehand in Queensland, Australia. Fourteen horses and one human being died. A novel virus was isolated from those affected and named equine morbillivirus (EMV). We report a case of encephalitis caused by this virus. A 35-year-old man from Queensland had a brief aseptic meningitic illness in August, 1994, shortly after caring for two horses that died from EMV infection and then assisting at their necropsies. He then suffered severe encephalitis 13 months later, characterised by uncontrolled focal and generalised epileptic activity. Rising titres of neutralising antibodies to EMV in the patient's serum at the time of the second illness suggested an anamnestic response. Distinctive cortical changes were shown on magnetic resonance neuroimaging and histopathological examination of the brain at necropsy. Immunohistochemistry and electronmicroscopy of brain tissue revealed pathology characteristic of the earlier cases of EMV infection. PCR on cerebrospinal fluid taken during the second illness, brain tissue, and serum retained from the original illness resulted in an amplified product identical to that previously described from E...Continue Reading

Citations

Sep 16, 2009·Archives of Neurology·Kenneth L Tyler
Jul 12, 2002·Annals of Neurology·Chong Tin TanMohd Rani Jusoh
May 3, 2008·Voprosy virusologii·A A KolomytsevN I Zakutskiĭ
Sep 3, 2013·Veterinary Microbiology·Emma L Croser, Glenn A Marsh
Oct 16, 2002·Thrombosis Research·Lutz Guertler
Mar 25, 1999·The Journal of Infection·J G McCormackP W Selleck
Sep 7, 2001·Journal of Virological Methods·I L SmithG A Smith
Sep 29, 1999·Veterinary Microbiology·P T HooperM M Williamson
May 4, 2001·Microbes and Infection·P DanielsB T Eaton
May 4, 2001·Microbes and Infection·A D HyattS G Hengstberger
May 4, 2001·Microbes and Infection·H FieldJ Mackenzie
May 4, 2001·Microbes and Infection·P HooperD Middleton
Nov 25, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·V T ChowJ Howe
Feb 19, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Paola CinqueAke Lundkvist
Mar 15, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Kaw Bing Chua
Apr 29, 2011·Epidemiology and Infection·A R SohayatiUNKNOWN Henipavirus Ecology Research Group
Dec 17, 2005·Nature Reviews. Microbiology·Bryan T EatonLin-Fa Wang
Aug 10, 2000·Neuropathology and Applied Neurobiology·K T Wong
Apr 27, 2000·The New England Journal of Medicine·K J GohS K Lam
Jul 26, 2011·New South Wales Public Health Bulletin·Beverley J PatersonDavid Smith
Jul 26, 2011·New South Wales Public Health Bulletin·Isabel M R HessTherese M Wright
Jul 5, 2012·The Journal of Biological Chemistry·Everett Clinton SmithRebecca Ellis Dutch
Jul 30, 2003·Animal Health Research Reviews·Christian GriotAndreas Zurbriggen
May 9, 2000·Australian and New Zealand Journal of Medicine·J G McCormack
Feb 11, 1999·Australian Veterinary Journal·M M WilliamsonP K Murray
Apr 17, 2001·Australian Veterinary Journal·P D KirklandK G Hart
Jul 19, 2006·Clinical Microbiology Reviews·Charles H CalisherTony Schountz
Aug 13, 2010·Journal of Virology·Everett Clinton Smith, Rebecca Ellis Dutch
Jul 27, 2007·Journal of Virology·M PorottoA Moscona
Jan 11, 2013·Journal of Virology·Olivier EscaffreBarry Rockx
Oct 3, 1998·BMJ : British Medical Journal·R A Weiss
Oct 8, 2005·BMC Evolutionary Biology·Mikkel H SchierupLaurids S Christensen

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.