PMID: 2495962Jan 1, 1989Paper

Fatal graft versus host disease after platelet transfusions in a child with purine nucleoside phosphorylase deficiency

European Journal of Pediatrics
S StrobelR J Levinsky

Abstract

Fatal graft versus host disease (GVHD) developed in a child with purine nucleoside phosphorylase (PNP) deficiency following an unirradiated platelet transfusion. IV treatment with an anti-T-cell monoclonal antibody (CD7) led to a transient improvement of his GVHD (Grade IV) but did not prevent the fatal outcome. This report emphasizes the need for blood products to be irradiated when cell mediated immunodeficiency is suspected, even in patients with residual immunocompetence.

Citations

Apr 26, 2002·British Journal of Haematology·Marlis L Schroeder
Mar 27, 2001·Postgraduate Medical Journal·K G Badami
Jan 1, 1997·APMIS. Supplementum·C B Andersen
Dec 6, 2008·Transfusion Medicine Reviews·Heiko RühlUlrich J H Sachs
Jul 17, 1998·Mathematical Biosciences·R CurtoM Cascante

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