Fatal graft-versus-host disease following HLA-mismatched donor lymphocyte infusion

Bone Marrow Transplantation
P J AmroliaD K Webb

Abstract

We report the case of a 10-year-old boy with molecular relapse of CML following unrelated donor BMT who developed fatal grade 4 acute GVHD of the gut and liver following one antigen-mismatched donor lymphocyte infusion. Previous experience of donor lymphocyte infusion in the HLA-mismatched setting is reviewed and the role of adoptive immunotherapy in this situation is discussed.

References

Jun 18, 1999·Annals of the New York Academy of Sciences·R HandgretingerT Klingebiel

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Citations

Sep 27, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shreemanta K ParidaMarkus Maeurer
Nov 30, 2016·Frontiers in Immunology·Monica ReisAnne Richter
Mar 12, 2020·Experimental Cell Research·Vikas Chander, Gurudutta Gangenahalli

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