Fatal hepatic failure after emergence of the hepatitis B virus mutant during lamivudine therapy in a patient with liver cirrhosis

Scandinavian Journal of Gastroenterology
J H WangY P Chou

Abstract

Lamivudine therapy for chronic hepatitis and decompensated liver cirrhosis related to the hepatitis B virus (HBV) resulted in improvement of liver function and inhibition of viral replication. Despite emergence of the HBV mutant, e-antigen seroconversion and improvement of liver function may be achieved with continuation of lamivudine therapy. Although hepatic decompensation has been reported in a few cases after the emergence of lamivudine-resistant mutants, fatal cases of non-transplant patients have only rarely been reported in the literature. Here, we describe a patient with HBV-related liver cirrhosis who died after a breakthrough infection with a lamivudine-resistant mutant. Hepatic failure and mortality developed after flare-up of severe hepatitis after 13 months of lamivudine treatment. Emergence of the HBV mutant with substitution of isoleucine for leucine at residue 426 (L4261) in combination with isoleucine for methionine at residue 550 (M5501) was observed at 10 and 13 months of treatment.

Citations

Oct 6, 2007·The Tohoku Journal of Experimental Medicine·Futoshi NagasakiTooru Shimosegawa
Sep 30, 2009·Virus Research·Ruth ChinJoseph Torresi
May 20, 2008·The Lancet Infectious Diseases·Kathryn L Nash, Graeme J M Alexander
Nov 27, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Yi-Hao YenChuan-Mo Lee
Apr 23, 2009·Virology·Richard A HeipertzHarriet C Isom
Feb 1, 2005·World Journal of Gastroenterology : WJG·Zhong-Min HuangMei-Jin Huang
Aug 31, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hyung Joon YimAnna S F Lok
Jul 12, 2008·Digestive Diseases and Sciences·Reiichiro KuwaharaMichio Sata
Jul 1, 2006·World Journal of Gastroenterology : WJG·Rui WangXin-Xiang Wan

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