Fatal hydrogen sulfide poisoning at a dye works

Legal Medicine
S KageK Kudo

Abstract

An adult Japanese man (A) entered a pit to remove sludge in a drainage pipe at a dye works in Japan. When he took off a joint of the pipe, the sludge in the pipe flowed into the pit. As he suddenly lost consciousness, three colleagues (B, C, D) entered the pit to rescue him. All of these (A, B, C and D) lost consciousness in the pit, and died soon after the accident. Since hydrogen sulfide gas was detected in the sludge of the pit, gas poisoning was suspected. Toxicological analyses of sulfide and thiosulfate, a metabolite of sulfide, in blood and urine of the victims were made, using the extractive alkylation technique combined with gas chromatography/mass spectrometry. Sulfide and thiosulfate were detected in whole blood of the four workers at levels of 0.32-9.36 mg/l and 0.11-0.23 mmol/l, respectively. These concentrations were at least 6-187 times higher in sulfide and 37-77 times higher in thiosulfate than those in healthy persons, and were similar to values found in fatal cases of hydrogen sulfide poisoning. Thiosulfate was not detected in the urine of four workers, which indicated acute death. Based on these results, all four patients were victims of hydrogen sulfide poisoning, who died soon after the exposure.

References

May 1, 1991·Journal of Analytical Toxicology·S KageK Kudo
May 18, 1968·Lancet·C L WinekC H Wecht
Sep 1, 1972·Biochemical Pharmacology·C G CurtisK S Dodgson
Jan 1, 1984·Critical Reviews in Toxicology·R O BeauchampD A Andjelkovich
Sep 1, 1981·Annals of Internal Medicine·L N Osbern, R O Crapo
Sep 15, 1980·Biochemical Pharmacology·T C BartholomewC G Curtis
Jan 1, 1996·International Journal of Legal Medicine·T ImamuraT Nagata
Jan 1, 1997·International Journal of Legal Medicine·S KageK Kudo

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Citations

Dec 12, 2007·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Michael A Policastro, Edward J Otten
Jun 14, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·E QuerellouJ-P Perfus
May 3, 2014·BioMed Research International·Xianqin WangGuanyang Lin
May 25, 2013·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Yoshito KamijoSatoshi Ishihara
Aug 14, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Hale DaldalHulya Sungurtekin
Jan 19, 2010·Forensic Science International : Synergy·D PoliR Gagliano-Candela
Mar 20, 2009·Forensic Science International : Synergy·Seong Hwan ParkJuck-Joon Hwang
Apr 21, 2009·Journal of Cellular and Molecular Medicine·Matthew Whiteman, Philip K Moore
Jun 19, 2013·Biochimica Et Biophysica Acta·Péter NagyAnita Vasas
Aug 31, 2013·BioMed Research International·Franco ScaldaferriAntonio Gasbarrini
Nov 8, 2013·The American Journal of Forensic Medicine and Pathology·Massimo LanciaRiccardo Rossi
Oct 30, 2013·Journal of Occupational and Environmental Medicine·Atkinson W LongmireRosemary K Sokas
Aug 8, 2020·Toxicology and Industrial Health·Weichun MoZhihua Zhang
Dec 22, 2016·The American Journal of Forensic Medicine and Pathology·Stephanie Sayre SmithChristopher P Weis
Jan 25, 2020·Forensic Science International : Synergy·Lucia AventaggiatoRoberto Gagliano-Candela
Jul 31, 2010·Archives of Pathology & Laboratory Medicine·Diane Ballerino-Regan, Atkinson W Longmire

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