PMID: 6538021Feb 1, 1984Paper

Fatal hyperpyrexia after withdrawal of levodopa

Neurology
G P SechiR Mutani

Abstract

We studied a patient affected with idiopathic Parkinson's disease and levodopa-induced dyskinesias. Fatal hyperpyrexia followed simultaneous levodopa withdrawal and a decrease in the dosage of diphenhydramine. The clinical features were those of the neuroleptic malignant syndrome. The rapid decrease in dopaminergic activity may have been important in causing the syndrome.

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