Fatal infection with emerging apicomplexan parasite Hepatozoon silvestris in a domestic cat

Parasites & Vectors
Kristel KeglerWalter Basso

Abstract

Hepatozoon silvestris is an emerging apicomplexan parasite discovered in European wild cats from Bosnia and Herzegovina and blood samples of a domestic cat from Southern Italy in 2017. It has also been identified in Ixodes ricinus collected from a domestic cat in Wales, UK, in 2018. The clinical relevance, pathogenesis and epidemiology of this novel Hepatozoon species are not yet understood. Thus, the objective of this paper was to report and describe the first fatal case of an H. silvestris infection in a domestic cat. The cat, which originated from Switzerland, died shortly after presenting clinical signs of lethargy, weakness and anorexia. At necropsy, no specific lesions were observed. Histopathology of the heart revealed a severe lympho-plasmacytic and histiocytic myocarditis. Mature and developing protozoal meronts morphologically compatible with Hepatozoon species were observed associated with the myocardial inflammation. No other lesions were present in any other organ evaluated, and the cat tested negative for retroviral and other immunosuppressive infectious agents. Polymerase chain reaction from the myocardium resulted in a specific amplicon of the Hepatozoon 18S rRNA gene. Sequencing and BLAST analysis revealed 100%...Continue Reading

References

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Citations

Jul 12, 2019·Journal of the South African Veterinary Association·David J HarrisRaquel Xavier
Oct 23, 2019·JFMS Open Reports·Maria A ErnandesAlice Tamborini
Dec 12, 2020·Animals : an Open Access Journal From MDPI·Valentina Virginia EbaniFrancesca Mancianti
Feb 27, 2021·Parasites & Vectors·Ingo SchäferElisabeth Müller
Apr 4, 2021·Veterinary Sciences·Alessandra GavazzaMatteo Cerquetella
Aug 12, 2021·Clinical Microbiology Reviews·Simone MorelliDonato Traversa
Nov 17, 2021·Journal of Feline Medicine and Surgery·Ingo SchäferElisabeth Müller

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Datasets Mentioned

BETA
MH078194

Methods Mentioned

BETA
PCR

Software Mentioned

MEGA7
jModelTest2
CLUSTALW
BLAST
SplitsTree4

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