Fatal intoxication with new synthetic cannabinoids AMB-FUBINACA and EMB-FUBINACA

Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Piotr AdamowiczMarta Maślanka

Abstract

Introduction: Synthetic cannabinoids are currently the largest group of new psychoactive substances. Those that have been subjected to legal control are replaced by newer uncontrolled substances, which causes constant and dynamic changes to the drug market. Some of the most recent synthetic cannabinoids that have appeared on the "legal highs" market are AMB-FUBINACA and EMB-FUBINACA. Case history: A 27-year-old man was found dead on a bed in an apartment. At autopsy, congestion of internal organs, pulmonary oedema and left-sided pleural adhesions were found. The medical examiner concluded that the man died due to acute respiratory failure. The autopsy materials (blood, urine, liver, kidney, stomach, intestine, lung and brain) were collected for further toxicological analyses. Methods: The synthetic cannabinoids AMB-FUBINACA and EMB-FUBINACA were isolated from autopsy materials by precipitation with acetonitrile. The quantitative analyses were carried out by LC-MS/MS. Results: AMB-FUBINACA and EMB-FUBINACA were detected and quantified in all post-mortem materials except the blood. The determined concentrations of these compounds in solid tissues were in the range of 0.2-0.9 ng/g and 0.2-3.5 ng/g. The highest concentrations of AM...Continue Reading

References

Apr 13, 2010·Journal of Forensic and Legal Medicine·Margaret M Stark, Guy A Norfolk
May 9, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kathryn A SeelyLiana Fattore
Aug 6, 2014·Mayo Clinic Proceedings·Benjamin L BickThomas F Mangan
Jan 24, 2015·Forensic Science International : Synergy·Yeter Erol ÖztürkBuket Alpertunga
Dec 16, 2016·The New England Journal of Medicine·Axel J AdamsRoy Gerona
Oct 23, 2018·Drug Testing and Analysis·Cameron S JohnsonAaron Lewis

❮ Previous
Next ❯

Citations

May 13, 2020·Annals of the New York Academy of Sciences·F Ivy CarrollP Anantha Reddy
Apr 7, 2020·Archives of Toxicology·Dino Luethi, Matthias E Liechti
Aug 4, 2020·EClinicalMedicine·Paul L MorrowRichard Massey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Related Papers

Forensic Science International : Synergy
Piotr Adamowicz
Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Piotr Adamowicz, Piotr Hydzik
Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Piotr Adamowicz, Joanna Gieroń
Journal of Analytical Toxicology
Shawn P VorceThomas Z Bosy
Journal of Forensic Sciences
Cristian PalmiereMarc Augsburger
© 2022 Meta ULC. All rights reserved