Abstract
Introduction: Synthetic cannabinoids are currently the largest group of new psychoactive substances. Those that have been subjected to legal control are replaced by newer uncontrolled substances, which causes constant and dynamic changes to the drug market. Some of the most recent synthetic cannabinoids that have appeared on the "legal highs" market are AMB-FUBINACA and EMB-FUBINACA. Case history: A 27-year-old man was found dead on a bed in an apartment. At autopsy, congestion of internal organs, pulmonary oedema and left-sided pleural adhesions were found. The medical examiner concluded that the man died due to acute respiratory failure. The autopsy materials (blood, urine, liver, kidney, stomach, intestine, lung and brain) were collected for further toxicological analyses. Methods: The synthetic cannabinoids AMB-FUBINACA and EMB-FUBINACA were isolated from autopsy materials by precipitation with acetonitrile. The quantitative analyses were carried out by LC-MS/MS. Results: AMB-FUBINACA and EMB-FUBINACA were detected and quantified in all post-mortem materials except the blood. The determined concentrations of these compounds in solid tissues were in the range of 0.2-0.9 ng/g and 0.2-3.5 ng/g. The highest concentrations of AM...Continue Reading
References
Apr 13, 2010·Journal of Forensic and Legal Medicine·Margaret M Stark, Guy A Norfolk
May 9, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kathryn A SeelyLiana Fattore
Aug 6, 2014·Mayo Clinic Proceedings·Benjamin L BickThomas F Mangan
Jan 24, 2015·Forensic Science International : Synergy·Yeter Erol ÖztürkBuket Alpertunga
Apr 26, 2015·Analytica Chimica Acta·Joanna ZnalezionaVítězslav Maier
May 16, 2015·Drug Testing and Analysis·Piotr Adamowicz, Bogdan Tokarczyk
Apr 15, 2016·Current Psychiatry Reports·Ziva D Cooper
Oct 23, 2016·The Journal of Emergency Medicine·Richard J HamiltonSahil S Banka
Dec 16, 2016·The New England Journal of Medicine·Axel J AdamsRoy Gerona
Nov 8, 2017·Scientific Reports·Atheer ZgairPavel Gershkovich
Jan 26, 2018·Forensic Toxicology·Takahiro DoiYoshiyuki Sawabe
Mar 20, 2018·The Journal of Pharmacology and Experimental Therapeutics·Thomas F GamageBrian F Thomas
Jul 3, 2018·Forensic Toxicology·Katarzyna Ambroziak, Piotr Adamowicz
Oct 23, 2018·Drug Testing and Analysis·Cameron S JohnsonAaron Lewis
Citations
Sep 19, 2019·Biomolecules·Marilisa P DimmitoAdriano Mollica
May 13, 2020·Annals of the New York Academy of Sciences·F Ivy CarrollP Anantha Reddy
May 18, 2020·Biomedical Chromatography : BMC·Brandon C PresleySusan A Jansen-Varnum
Dec 20, 2019·Drug Testing and Analysis·Ryan M Alam, John J Keating
Apr 7, 2020·Archives of Toxicology·Dino Luethi, Matthias E Liechti
Aug 4, 2020·EClinicalMedicine·Paul L MorrowRichard Massey
Mar 7, 2021·Pharmaceuticals·Carolina Lobato-FreitasDiana Dias-da-Silva
May 18, 2021·Neuropharmacology·Jamie J ManningDavid B Finlay
Sep 13, 2019·ACS Chemical Neuroscience·David B FinlayMichelle Glass
Aug 29, 2021·Archives of Toxicology·Tanja M GampferMarkus R Meyer
Dec 18, 2021·Journal of Analytical Toxicology·Ziteng WangEric Chun Yong Chan