PMID: 8599186Oct 1, 1995Paper

Fatal mass poisoning in Madagascar following ingestion of a shark (Carcharhinus leucas): clinical and epidemiological aspects and isolation of toxins

Toxicon : Official Journal of the International Society on Toxinology
P BoisierT Yasumoto

Abstract

In November 1993, 188 people were admitted to hospital after eating the meat from a single shark (Carcharhinus leucas) in Manakara, a medium-sized town on the south-east coast of Madagascar. This shark and its meat had no unusual characteristics. The attack rate was about 100%. The first clinical signs appeared within 5-10 hr after ingestion. The patients presented with neurological symptoms almost exclusively, the most prominent being a constant, severe ataxia. Gastrointestinal troubles, like diarrhoea and vomiting, were rare. The overall case mortality ratio was close to 30% among the 200 poisoned inhabitants. There were no reports of previous similar poisonings in this area, and fishermen in Manakara usually eat this kind of shark without problems. Bacteriological and chemical causes were eliminated. Two liposoluble toxins were isolated from the liver and tentatively named carchatoxin-A and -B, respectively. They were distinct from ciguatoxin in their chromatographic properties.

References

Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·U AnthoniP Nielsen
Dec 1, 1969·Toxicon : Official Journal of the International Society on Toxinology·T Yasumoto, P J Scheuer

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Citations

Aug 15, 2002·Toxicon : Official Journal of the International Society on Toxinology·Brett HamiltonRichard J Lewis
Oct 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeremy Sobel, John Painter
Jun 23, 2009·Toxicon : Official Journal of the International Society on Toxinology·Brett HamiltonRichard J Lewis
Jan 22, 2008·Toxicon : Official Journal of the International Society on Toxinology·C GattiA M Legrand
Jun 12, 2016·Toxicon : Official Journal of the International Society on Toxinology·Lauren MeyerColin Simpfendorfer
Mar 22, 2005·Lancet Neurology·Geoffrey K Isbister, Matthew C Kiernan
Jan 10, 2019·Marine Drugs·Isidro José TameleVitor Vasconcelos
Apr 21, 2021·Harmful Algae·M ChinainP A Tester
Jan 5, 2002·Wilderness & Environmental Medicine·D J Farstad, T Chow

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