Fatal mechanical asphyxia induces changes in energy utilization in the rat brain: An (18)F-FDG-PET study

Legal Medicine
Suhua MaLi Quan

Abstract

This study was designed to evaluate changes in brain glucose metabolism in rats following ligature strangulation. Thirteen male Wistar rats were used in the present study, divided into control (n=7) and asphyxia groups (n=6, ligature strangulation). Positron emission tomography (PET) with 2-deoxy-2-[(18)F]fluoro-D-glucose ((18)F-FDG) was used to evaluate brain glucose metabolism. Rats were scanned for PET-CT, and image data co-registered with a T2WI MRI template using SPM8 software. Image J was employed to draw regions of interest (ROIs) from the MRI template and acquire ROI activity information from the PET images. In the asphyxia group vs. controls, (18)F-FDG uptake (FU) was decreased in the substantia nigra (25.26%, p<0.001), rhombencephalon (pons/medulla oblongata, 13.92%, p<0.01), hypothalamus (22.06%, p<0.01), ventral tegmentum (10.12%, p<0.05) and amygdala (12.74%, p<0.05); however, FU was increased in motor (18.21%, p<0.05) and visual cortices (19.2%, p<0.05). The glucose metabolism distribution map in the asphyxiated rat brains were substantially changed versus controls. PET with (18)F-FDG can demonstrate excitement and inhibition of different brain areas even in cases of ligature strangulation.

References

Oct 1, 1988·Critical Care Medicine·J H Garcia
Nov 7, 1999·International Journal of Legal Medicine·M NogamiI Ishiyama
Mar 30, 2000·The American Journal of Forensic Medicine and Pathology·V J DiMaio
Feb 13, 2001·Progress in Neurobiology·D CentonzeP Calabresi
Jun 8, 2001·The American Journal of Forensic Medicine and Pathology·V J DiMaio, J R Francis
Jan 5, 2002·The American Journal of Forensic Medicine and Pathology·R E KohlmeierV J DiMaio
Mar 26, 2003·ILAR Journal·Richard J Traystman
Aug 25, 2004·Lancet Neurology·Steven LaureysNicholas D Schiff
Aug 2, 2005·Legal Medicine·Satish K Verma, Sone Lal
Jun 2, 2006·The American Journal of Forensic Medicine and Pathology·Derya Azmak
Nov 28, 2008·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·M L Soto-MontenegroM Desco
Apr 23, 2009·Physics in Medicine and Biology·Cristian C Constantinescu, Jogeshwar Mukherjee
Jun 2, 2009·Journal of Forensic and Legal Medicine·Serafettin DemirciGursel Gunaydin
Jun 22, 2010·Journal of Forensic Sciences·Anny Sauvageau, Elie Boghossian
Jul 6, 2010·Trends in Pharmacological Sciences·Sophie Lancelot, Luc Zimmer
Jul 30, 2010·Psychophysiology·Peter J LangVincent D Costa
Mar 20, 2012·Acta neurologica Belgica·Marco LuigettiAlessandro Cianfoni
Nov 23, 2012·Current Drug Targets·Jake T NeumannMiguel A Perez-Pinzon
Oct 8, 2013·Seminars in Nuclear Medicine·Ilya Nasrallah, Jacob Dubroff

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Citations

Dec 29, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Junyun HeXiaofeng Jia
Jan 11, 2017·The American Journal of Forensic Medicine and Pathology·Xueying FengLi Quan

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