Fatal Outcome in a Kidney-Pancreas Transplant Recipient With COVID-19

Curēus
Kulachanya Suwanwongse, Nehad Shabarek

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious pathogen causing the novel coronavirus disease 2019 (COVID-19), the ongoing unprecedented pandemic in 2020. SARS-CoV-2 primarily targets the respiratory systems, so acute respiratory distress syndrome is the major cause of death. Clinical courses of COVID-19 are variable and unpredictable, while some epidemiologic and clinical factors have been found to have a negative impact on the disease prognosis. Despite a growing report on clinical characteristics and prognosis of patients with COVID-19, the data in the special population, including transplant recipients, is still limited. Herein we report on the clinical features and fatal outcome of COVID-19 in a dual pancreas-kidney transplant recipient (with failure of the pancreas graft). Our case illustrates the similarities and differences of the COVID-19 disease course between transplant recipients and the general population. We proposed that the pre-existing T-cell dysfunction from the long-term use of immunosuppressive agents in organ transplant recipients adversely affects COVID-19 prognosis and worsens COVID-19 mortality.

References

Mar 13, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chuan QinDai-Shi Tian
Mar 18, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Lan ZhuGang Chen
Apr 13, 2020·The Lancet. Gastroenterology & Hepatology·Sherrie BhooriVincenzo Mazzaferro
Apr 15, 2020·International Journal of Surgery·Maria NicolaRiaz Agha
Apr 18, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Mario Fernández-RuizJosé M Aguado
Apr 23, 2020·Cell Host & Microbe·Evangelos J Giamarellos-BourboulisAntonia Koutsoukou
Apr 25, 2020·The New England Journal of Medicine·Enver AkalinMilan Kinkhabwala
Apr 25, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Marcus R PereiraElizabeth C Verna
May 22, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Feng GaoMing-Hua Zheng
May 23, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Umberto MaggioreBruno Watschinger
May 29, 2020·Journal of Medical Virology·Kulachanya Suwanwongse, Nehad Shabarek
Jun 1, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marco MerliMassimo Puoti
Jun 2, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Monica FungJennifer M Babik

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Citations

Jun 28, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Monica Fung, Jennifer M Babik
Jun 23, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Yifei HuSten H Vermund
Jun 23, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Leonardo CalzaPierluigi Viale
Sep 5, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Chia Siang Kow, Syed Shahzad Hasan

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Methods Mentioned

BETA
biopsy

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