Fatal parvovirus B19 infections: a report of two autopsy cases

International Journal of Legal Medicine
Hsuan-Yun HuChih-Hsin Pan

Abstract

Parvovirus B19 (PVB19) commonly infects children and is usually asymptomatic. Lethal outcomes of PVB19 infection are unusual; nevertheless, the two cases reported here are rare examples of PVB19-induced hemophagocytic syndrome and myocarditis in infants and children. The two cases show the indisputable usefulness of immunohistochemistry and in situ hybridization in the detection of PVB19. In the death investigations, histopathological examinations provided stronger evidence than did serology or molecular biology. The cases also highlight the importance of forensic autopsy in vaccine-related death. As vaccine-related deaths are what people fear and may cause declines in vaccination rates, it is important to clarify deaths temporally or causally associated with vaccine administration.

References

Jun 1, 1990·The Journal of Pediatrics·J Saint-MartinF Morinet
Aug 24, 1989·The New England Journal of Medicine·L M BellS A Plotkin
Sep 1, 1986·The Journal of Infectious Diseases·T ChorbaR Moir
Apr 1, 1995·British Journal of Haematology·K Shirono, H Tsuda
Mar 1, 1997·European Heart Journal·T OrthK H Meyer zum Bûschenfelde
Mar 21, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G EndersK E Brown
May 5, 1999·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·Y MatsumotoY Sugiura
Mar 29, 2001·Human Pathology·C E MurryD D Reichenbach
Nov 29, 2001·Journal of Clinical Microbiology·J RohayemA Rethwilm
Jul 5, 2002·Clinical Microbiology Reviews·Erik D Heegaard, Kevin E Brown
Oct 18, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nikos PapadogiannakisKristina Broliden
Mar 19, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Patrycja JonetzkoGerhard Poelzl
Mar 4, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Julia DinaFrançois Freymuth
Sep 25, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Amanjit BalS K Jindal
Dec 17, 2011·The Pediatric Infectious Disease Journal·Berengere KoehlMarianne Leruez-Ville
Jan 18, 2012·Current Opinion in Obstetrics & Gynecology·Anneke C DijkmansDick Oepkes
Feb 2, 2012·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Maico TaveraDomingo Casadei
Mar 20, 2012·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Scott A KoepsellStanley J Radio
Oct 2, 2012·Paediatrics & Child Health·Keswadee Lapphra, David Scheifele
Jun 29, 2013·Human Vaccines & Immunotherapeutics·David Ropeik
Jun 17, 2014·Journal of Forensic and Legal Medicine·Zoltan JuhaszEva Kereszty
Jul 9, 2014·Obstetrics and Gynecology·Michinori MayamaHidenori Oguchi
Oct 21, 2014·Case Reports in Obstetrics and Gynecology·Atsuko Hichijo, Mikio Morine
Aug 26, 2017·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Lisa A GrohskopfDaniel B Jernigan

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Albert J EidRaymund R Razonable
Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Julia DinaAstrid Vabret
© 2022 Meta ULC. All rights reserved