Fatal poxvirus outbreak in a colony of New World monkeys

Veterinary Pathology
K Mätz-RensingF-J Kaup

Abstract

An epizootic infection was observed in a colony of 80 New World monkeys consisting of various species including a group of marmosets and Saguinus species. During the summer and autumn of 2002, 30 animals died of unknown diseases. Six animals were sent to the German Primate Center for investigation of the cause of death. A complete pathologic and histologic investigation was carried out. The animals exhibited erosive-ulcerative lesions of the oral mucous membranes. Advanced stages of the disease were characterised by hemorrhagic lesions on the skin distributed randomly over the body, but principally on the face, scrotal region, soles, and palms. Electron microscopy revealed virus particles with orthopox-like morphology within intracytoplasmic inclusions in epithelial cells. The DNA samples from various tissues were analyzed by use of a set of orthopox virus-specific, real-time polymerase chain reaction assays. Amplification products were sequenced to define the virus more precisely. Sequencing confirmed the presence of an orthopox virus. Sequence data indicated that all six animals were infected with the same virus. Propagation of the virus on Vero cells resulted in a rapidly progressive cytopathogenic effect. Preliminary phylog...Continue Reading

References

Feb 24, 1979·The Veterinary Record·D BaxbyE M Denham
Aug 1, 1991·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·C P CzernyB Pfeiff
Jul 1, 1985·The American Journal of Tropical Medicine and Hygiene·I AritaK Ruti
Jan 1, 1997·Archives of Virology. Supplementum·D Baxby, M Bennett
Aug 15, 1998·Journal of Clinical Microbiology·T SandvikT Traavik
Aug 25, 1999·Epidemiology and Infection·J ChantreyM Bennett

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Citations

Apr 3, 2014·Vector Borne and Zoonotic Diseases·Donata KalthoffBernd Hoffmann
Apr 6, 2011·Research in Veterinary Science·Hartwig P HuemerNorbert Nowotny
Jul 17, 2008·Biology of the Cell·Philippe Roingeard
Mar 8, 2011·Veterinary Dermatology·Vanessa HerderAndreas Beineke
Jan 5, 2011·Immunological Reviews·Bernard Moss
Sep 24, 2011·The Journal of General Virology·Alvin L SmithReed F Johnson
Dec 4, 2009·Virology·Kristina E RehmRachel L Roper
Aug 3, 2010·Microbes and Infection·Dina Alzhanova, Klaus Früh
Dec 3, 2014·European Journal of Medicinal Chemistry·Ana P GuimarãesTanos C C França
Sep 4, 2013·Journal of Biomolecular Structure & Dynamics·Ana Paula GuimarãesTanos Celmar Costa França
May 18, 2010·Veterinary Pathology·G SchmiedeknechtM Reinacher
Oct 5, 2017·Emerging Infectious Diseases·Giusy CardetiGian Luca Autorino
Nov 10, 2018·Reviews in Medical Virology·Philippe RoingeardEmmanuelle Blanchard
Oct 28, 2019·Journal of Virology·Aistė TamošiūnaitėNikolaus Osterrieder
Jan 1, 2011·Animals : an Open Access Journal From MDPI·Danielle M Tack, Mary G Reynolds
Feb 26, 2020·Viruses·Almut PrknoAlexander Starke
Sep 23, 2018·Primates; Journal of Primatology·Ivan Puga-GonzalezCedric Sueur
Jul 12, 2011·The Veterinary Record·S J GirlingP M Beard
Jan 6, 2021·Viruses·Natalia Ingrid Oliveira SilvaBetânia Paiva Drumond
Aug 14, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Luane Jandira Bueno LandauMaria Cátira Bortolini

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Methods Mentioned

BETA
ELISA
PCR

Software Mentioned

DNA Star Lasergene Computer

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