Fatal pulmonary embolism and antithrombin III deficiency in adult lymphoblastic leukaemia during L-asparaginase therapy

Acta Haematologica
T BarbuiE Dini

Abstract

We describe 2 adult patients with acute lymphoblastic leukaemia (ALL) who died from pulmonary embolism following L-asparaginase treatment. Since this drug is known to cause a decrease in antithrombin III, the most important protein physiologically involved in the neutralization of thrombin, we studied the behaviour of this inhibitor in 14 ALL patients treated with a protocol including a 14-day course of L-asparaginase. A significant but transient fall of biological and immunological antithrombin III and a concomitant reduction of fibrinogen were documented.

Citations

Jan 1, 1992·Veterinary Clinical Pathology·Carol P. MandellBernard F. Feldman
Aug 1, 1986·Blut·I Pabinger
Oct 24, 2014·Thrombosis and Haemostasis·V De StefanoE Rossi
Nov 1, 1995·European Journal of Haematology·H CarlssonJ Kutti
Jan 1, 1985·Hematological Oncology·T BarbuiE Dini

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