Fatal pulmonary fibrosis induced by paclitaxel: a case report and review of the literature

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
G OstorosB Dome

Abstract

Fatal lung fibrosis caused by paclitaxel toxicity has not been reported In this report, we describe the case of a 62-year-old woman who received six cycles of paclitaxel and carboplatin as combination chemotherapy for advanced ovarian cancer. Four weeks after the end of the chemotherapy she developed interstitial pneumonitis and irreversible lung fibrosis. Despite treatment with corticosteroids, she had rapid deterioration and died of respiratory failure. Pulmonary fibrosis is a complication of paclitaxel therapy that may occur despite treatments with corticosteroids. While reviewing the literature, we found few less severe pulmonary injuries after intravenous use of paclitaxel, but none of these cases had a fatal outcome. Physicians should keep in mind that taxanes such as paclitaxel have the potential to cause pneumonitis and lung fibrosis.

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Citations

Nov 30, 2006·Cancer Immunology, Immunotherapy : CII·A St SwierzkoZ Sułowska
Mar 5, 2014·Drug Design, Development and Therapy·Dongshan ZhangZheng Dong
Jun 17, 2011·Future Oncology·Kate M StamplerCharles J Dunton
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Jun 18, 2021·Respirology Case Reports·Sanjeewa Malinda HettiarachchiEshanth Perera

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