PMID: 9174542Apr 1, 1997Paper

Fatal pulmonary hemorrhage in patients with acute leukemia and fulminant pneumonia caused by Stenotrophomonas maltophilia

Annals of Hematology
H A ElsnerD K Hossfeld

Abstract

Pulmonary hemorrhage is a rare cause of death in patients with acute leukemia. Within a 3-month period we observed three such cases, all of which were associated with the gram-negative opportunistic pathogen Stenotrophomonas maltophilia. Since fatal lung bleeding had previously not been observed in conjunction with this organism, we collected the data from all patients with documented S. maltophilia infections or colonizations of the past year and analyzed the risk factors for a lethal outcome. A total of eight patients were identified. In the three patients with fatal hemorrhage, the interval between first complaints (chest pain, cough, fever) and death from lung bleeding was 36-72 h. A fourth patient with acute leukemia died of nonhemorrhagic respiratory failure 9 days after developing S. maltophilia-associated pneumonia. All four patients had received intensive chemotherapy and were severely neutropenic and thrombocytopenic. Such a combination of predisposing factors was not observed in the four patients with nonfatal infections or colonizations. Pulsed-field gel electrophoresis demonstrated that the infections were unrelated. S. maltophilia was also isolated from a faucet in a patient's room, but the strain isolated was gen...Continue Reading

Citations

Feb 19, 2009·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M E FalagasG Dimopoulos
Nov 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C A SattlerS L Kaplan
Jul 30, 2008·The Journal of Antimicrobial Chemotherapy·Matthew E FalagasPo-Ren Hsueh
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Mar 5, 2005·Applied and Environmental Microbiology·Hsiao-Chuan ChangShu-Fen Weng
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Jun 10, 2011·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Naoto TakahashiKenichi Sawada
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Nov 14, 2018·Infectious Diseases·Angelina Trifonova, Tanya Strateva
Jul 4, 2012·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Minako MoriKazunori Imada
May 10, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Valeriy PoroykoKonstantin G Birukov
Aug 31, 2017·Annals of Clinical Microbiology and Antimicrobials·David M PierreJanet E Stout
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Feb 7, 2018·Indian Journal of Medical Microbiology·Lipika SinghalVikas Gautam

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