Fatal Tuberculosis in a Free-Ranging African Elephant and One Health Implications of Human Pathogens in Wildlife

Frontiers in Veterinary Science
Michele MillerPaul van Helden

Abstract

Tuberculosis (TB) in humans is a global public health concern and the discovery of animal cases of Mycobacterium tuberculosis (Mtb) infection and disease, especially in multi-host settings, also has significant implications for public health, veterinary disease control, and conservation endeavors. This paper describes a fatal case of Mtb disease in a free-ranging African elephant (Loxodonta africana) in a high human TB burden region. Necropsy revealed extensive granulomatous pneumonia, from which Mtb was isolated and identified as a member of LAM3/F11 lineage; a common lineage found in humans in South Africa. These findings are contextualized within a framework of emerging Mtb disease in wildlife globally and highlights the importance of the One Health paradigm in addressing this anthroponotic threat to wildlife and the zoonotic implications.

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Citations

Oct 1, 2020·Animals : an Open Access Journal From MDPI·Katie L EdwardsJanine L Brown
Jan 11, 2021·Transboundary and Emerging Diseases·Tanya J KerrMichele A Miller
Feb 25, 2021·Emerging Infectious Diseases·Michele A MillerPeter E Buss

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Datasets Mentioned

BETA
PRJNA430907

Methods Mentioned

BETA
PCR
bronchoalveolar lavage

Software Mentioned

MAPIA

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