Fatal vitamin C-associated acute renal failure

Anaesthesia and Intensive Care
G J McHughR C Freebairn

Abstract

Although daily ingestion of high-dose vitamin C is generally regarded as largely innocuous, fatal nephrotoxicity can occur in some rare circumstances. We report a case where the patient, who chose to forgo any advanced conventional medical intervention (dialysis and mechanical ventilation), had failed to disclose his use of high-dose vitamin C and subsequently died. Intra-renal oxalate crystal deposition was demonstrated at autopsy. Directed enquiry with the family then revealed his high-dose vitamin C usage. Even though fully-informed discussion was limited by incomplete prospective disclosure, it remains the prerogative of any competent patient to decline any treatment, including those that may be considered life-saving.

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Citations

Nov 20, 2018·JPEN. Journal of Parenteral and Enteral Nutrition·Pascal L LangloisDaren K Heyland
May 24, 2011·International Journal of Nephrology·Jorge LamarcheCraig Courville
Mar 24, 2016·Urolithiasis·John KnightRoss P Holmes
May 18, 2018·Integrative Cancer Therapies·Anthony J BazzanDaniel A Monti
Jun 18, 2015·Journal of Physiology and Biochemistry·Esther LopezPedro C Redondo
Oct 3, 2018·CEN Case Reports·Weijie Violet LinGregory Constantine
Apr 30, 2021·Critical Care Explorations·Tasheen WissanjiHan Ting Wang

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