PMID: 7535927Mar 28, 1995Paper

Fate of a redundant gamma-globin gene in the atelid clade of New World monkeys: implications concerning fetal globin gene expression

Proceedings of the National Academy of Sciences of the United States of America
C MeirelesM Goodman

Abstract

Conclusive evidence was provided that gamma 1, the upstream of the two linked simian gamma-globin loci (5'-gamma 1-gamma 2-3'), is a pseudogene in a major group of New World monkeys. Sequence analysis of PCR-amplified genomic fragments of predicted sizes revealed that all extant genera of the platyrrhine family Atelidae [Lagothrix (woolly monkeys), Brachyteles (woolly spider monkeys), Ateles (spider monkeys), and Alouatta (howler monkeys)] share a large deletion that removed most of exon 2, all of intron 2 and exon 3, and much of the 3' flanking sequence of gamma 1. The fact that two functional gamma-globin genes were not present in early ancestors of the Atelidae (and that gamma 1 was the dispensible gene) suggests that for much or even all of their evolution, platyrrhines have had gamma 2 as the primary fetally expressed gamma-globin gene, in contrast to catarrhines (e.g., humans and chimpanzees) that have gamma 1 as the primary fetally expressed gamma-globin gene. Results from promoter sequences further suggest that all three platyrrhine families (Atelidae, Cebidae, and Pitheciidae) have gamma 2 rather than gamma 1 as their primary fetally expressed gamma-globin gene. The implications of this suggestion were explored in term...Continue Reading

References

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Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S J Cooper, R M Hope

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Citations

Oct 16, 2004·Journal of Molecular Evolution·Gabriela AguiletaZiheng Yang
Nov 22, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Robert M JohnsonMorris Goodman
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·C H ChiuM Goodman
Sep 29, 2006·Primates; Journal of Primatology·Margarida Maria Celeira de LimaHoracio Schneider
Mar 1, 1997·Hemoglobin·R M JohnsonM Goodman
Nov 7, 2015·Evolutionary Bioinformatics Online·Gisele Cristine de Souza CarrociniClaudia Regina Bonini-Domingos
Jul 15, 2004·American Journal of Physical Anthropology·A C Collins
Jan 6, 2001·The Journal of Experimental Zoology·R M JohnsonM Goodman
Jun 21, 1996·The Journal of Biological Chemistry·R M JohnsonM Goodman
Jul 26, 2002·Journal of Inherited Metabolic Disease·D N Cooper
Dec 22, 1999·Molecular Phylogenetics and Evolution·S L PageM Goodman
Feb 19, 2000·Molecular Phylogenetics and Evolution·Y SattaN Takahata
Jan 23, 1999·American Journal of Human Genetics·M Goodman

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