PMID: 2508038Aug 1, 1989Paper

Fate of attenuated schistosomula administered to mice by different routes, relative to the immunity induced against Schistosoma mansoni

Parasitology
P S Coulson, A P Mountford

Abstract

Newly transformed schistosomula and day 8 lung parasites, derived from optimally irradiated cercariae, were used to immunize groups of C57Bl/6 mice via 4 different injection routes. Schistosomula administered intradermally induced high levels of protection, comparable with that achieved by percutaneous vaccination. Intermediate levels were elicited by delivery of parasites via intraperitoneal or intratracheal routes. In contrast, intravenous injection of schistosomula to the lungs resulted in little or no resistance. Attenuated day 8 schistosomula administered intradermally were at least as immunogenic as irradiated cercariae. The fate of radio-isotope labelled attenuated lung schistosomula, injected via the various routes, was examined by compressed organ autoradiography. After intradermal vaccination, a proportion of parasites migrated from the site of injection to the draining lymph node and lungs. Conversely, schistosomula administered via the other 3 routes persisted to varying degrees at the injection site, but little onward migration was observed. We suggest that successful vaccination requires that some attenuated parasites migrate to, and sequester in, lymph nodes draining the vaccination site; persistence at the site ...Continue Reading

References

Apr 1, 1979·Experimental Parasitology·S N Chen, R E Howells
Jun 1, 1987·Experimental Parasitology·S L James
Nov 1, 1987·The American Journal of Tropical Medicine and Hygiene·R AitkenR A Wilson
May 1, 1988·The American Journal of Tropical Medicine and Hygiene·P S Coulson, R A Wilson
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Jan 1, 1980·Immunological Reviews·M I Greene, B Benacerraf
Mar 1, 1982·Parasite Immunology·A Sher, D Benno

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Citations

May 18, 2001·Veterinary Immunology and Immunopathology·B D Hunsaker, L J Perino
Oct 17, 2006·Parasitology Today·A P Mountford, R Harrop
Mar 1, 1991·Immunology Today·N Schweitzer, R Anderson
Apr 24, 2004·Trends in Parasitology·Adrian P Mountford, Francois Trottein
Aug 1, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A P MountfordS Anderson
Jan 1, 1991·Revista Do Instituto De Medicina Tropical De São Paulo·P M CoelhoS E Gerken
Mar 15, 2006·Brazilian Journal of Biology = Revista Brasleira De Biologia·M M Vilar, R M Pinto
May 8, 2001·Revista Do Instituto De Medicina Tropical De São Paulo·A L Melo, M Chamone
Sep 6, 2005·Parasite Immunology·J P HewitsonA P Mountford

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