Fate of metronidazole following intravaginal and intravenous administration to rabbits

Journal of Toxicology and Environmental Health
H S Buttar


The rate and extent of transvaginal absorption and the disposition of [14C]-metronidazole ([14C]MTZ) were compared during the first 6 h after intravaginal (ivg) and intravenous (iv) administration of 10 mg/kg to adult female rabbits. Upon ivg administration, peak blood 14C levels were reached at 20 min, remained steady up to 1 h, and thereafter followed a decline similar to that of the iv injected group. Following ivg application, both the area under the blood 14C concentration versus time curve (AUC) and the elimination half-life (t1/2) of 14C from blood during the beta-phase were similar to those of iv injected females. Less than 1% of the administered radioactivity was recovered from the vagina after 5 h. Urine was the main channel of 14C excretion, and only 5--8% of the administered dose was recovered in bile during 6 h in either treatment group. The combined excretions of 14C in the urine, bile, and feces were similar (ivg = 72.2 +/- 4.5 and iv = 66.6 +/- 1.9% of dose) in both groups. At the end of 6 h, the levels of 14C were highest in the urinary bladder, liver, and kidney, followed by those in the duodenum, cecum, and uterus, but lowest in fat after both iv and ivg treatments. Unchanged [14C]MTZ and five of its metaboli...Continue Reading


Sep 1, 1978·The Journal of Antimicrobial Chemotherapy·S J Eykyn, I Phillips
Aug 1, 1979·The Journal of Pharmacy and Pharmacology·H S ButtarJ H Moffatt
Sep 1, 1978·The Journal of Antimicrobial Chemotherapy·E J Baines
Jun 29, 1978·The New England Journal of Medicine·T A PheiferK K Holmes
May 1, 1977·The Journal of Antimicrobial Chemotherapy·F J Roe
Jan 1, 1978·The Journal of Antimicrobial Chemotherapy·J De LouvoisR Hurley
Apr 1, 1975·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R M IngsW E Ormerod
Jan 1, 1974·Drug Metabolism Reviews·M Gibaldi, D Perrier
Feb 1, 1980·The British Journal of Surgery·A F HigginsM L Hole

Related Concepts

Process of Absorption
Intravenous Injections
Bayer 5360
Drug or Chemical Tissue Distribution

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.