Fate of the metabolically healthy obese-is this term a misnomer? A study from the Clinical Practice Research Datalink

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Osama MoussaSanjay Purkayastha

Abstract

The metabolically healthy obese (MHO) phenotype may express typical characteristics on long-term follow-up. Little is known about the initiation of this phenotypes and its future stability. The Clinical Practice Research Datalink (CPRD) is a large-scale primary care database. The aim of this study was to assess the stability of, and evaluate the factors associated with a transition into an unhealthy outcome in, a MHO population in the UK. The CPRD was interrogated for a diagnosis of 'obesity' and cross-referenced with a body mass index (BMI) ≥35 kg/m2; participants were further classified as MH using a clinical diagnostic code or a relative therapeutic code. A hazard cox regression univariate and multivariate analysis evaluated the time to transition for independent variables. There were 231,399 patients with a recorded BMI of 35 kg/m2 or greater. Incomplete records were eliminated and follow-up limited to 300 months, the cohort was reduced to 180,560 patients. The prevalence of MHO within the obese population from the CPRD was 128,191/180,560 (71%). MHO individuals, who were of male gender (hazard ratio (HR) 1.23 (1.21-1.25), p = < 0.01), older age group (HR 3.93 (3.82-4.04), p = < 0.01), BMI of 50-60 kg/m2 at baseline (HR 1.3...Continue Reading

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Citations

Jul 6, 2019·Obesity Surgery·Adriana Florinela Cătoi, Luca Busetto
Mar 5, 2020·Endocrine Reviews·Matthias Blüher
Sep 17, 2019·The Journal of Clinical Investigation·Gordon I SmithSamuel Klein
Dec 21, 2018·Diabetologia·Matthias B Schulze
Aug 24, 2020·European Journal of Internal Medicine·E SanidasJ Barbetseas
Apr 30, 2021·European Journal of Clinical Nutrition·Patricia CorralesGema Medina-Gómez

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