Fate of transient catecholaminergic cell types revealed by site-specific recombination in transgenic mice

Journal of Neuroscience Research
Natsuki MatsushitaKazuto Kobayashi

Abstract

Catecholamine-producing cell types are generated from specified neuronal lineages during vertebrate development. The catecholaminergic phenotype is also expressed transiently in some cell types in non-catecholaminergic tissues, including the sensory ganglia, enteric ganglia, and ventral portions of the neural tube during embryonic development. The fate of the transient catecholaminergic cell types at later developmental stages, however, has not been elucidated. We developed a Cre-loxP-mediated recombination system under the control of the dopamine beta-hydroxylase (DBH) promoter, which drives gene expression in typical noradrenergic and adrenergic cell groups as well as in transient catecholaminergic cell types. Expression of Cre recombinase in transgenic mice resulted in an efficient recombination in noradrenergic and adrenergic cell groups at the adult stage. The recombination was also induced in the cranial nerve/spinal cord motor neurons and sensory/enteric ganglion neurons. Analysis of recombination patterns in transgenic mouse embryos showed the occurrence of recombination during prenatal development in both cell types exhibiting the typical and transient catecholaminergic phenotypes. Because the DBH gene promoter is expr...Continue Reading

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Citations

Mar 26, 2010·Autonomic Neuroscience : Basic & Clinical·Kensuke KimuraKeiichi Fukuda
Jan 12, 2011·The European Journal of Neuroscience·Kenta KobayashiKazuto Kobayashi
May 4, 2010·The Journal of Comparative Neurology·J Patrick CardAlan F Sved
Apr 23, 2005·Glia·Jennifer K NessMark P Goldberg
Jul 20, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mikiko OhnoEiichiro Nishi
Feb 18, 2021·Nature Communications·Takahiro HorieKoh Ono

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